Freeze-dried and frozen particulate bone allografts are used interchangeably on the assumption that the biologic behavior of these grafts is similar. Dissimilarities in biologic behavior and differences in the rate and extent of bone incorporation of freeze-dried and frozen particulate grafts were demonstrated in a comparative study using a non-human primate model. Freeze-dried particulate allografts induced new bone formation and healing of the osseous defects much faster than the frozen allografts.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cryobiol.2007.05.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Quantifying the effect of particulate impurities on the ice nucleation behavior of pharmaceutical solutions.
Int J Pharm
January 2025
Institute of Energy and Process Engineering, ETH Zurich, 8092 Zurich, Switzerland. Electronic address:
Numerous commercially available biopharmaceuticals are frozen or freeze-dried in vials. The temperature at which ice nucleates and its distribution across vials in a batch is critical to the design of freezing and freeze-drying processes. Here we study experimentally how the level of particulate impurities - a key parameter in pharmaceutical manufacturing - affects the ice nucleation behavior.
View Article and Find Full Text PDFMastoid Obliteration With Freeze-Dried Bone Allograft in Canal Wall Down Tympanoplasty: Description of a Novel Technique and Case Report.
Case Rep Surg
October 2024
Section of Otorhinolaryngology, Department of Neurosciences, University of Padova, Padova, Italy.
Mastoid obliteration can be performed after canal wall down (CWD) mastoidectomy with various materials. Homologous bone tissue harvested from cadaver donor represents a feasible option with advantages. The purpose of the study is to describe the case of a patient diagnosed with middle ear cholesteatoma treated with mastoidectomy of the CWD and mastoid obliteration with homologous freeze-dried corticocancellous bone particulate in the Cittadella Hospital Ear, Nose, Throat (ENT) unit.
View Article and Find Full Text PDFOptimization, Formulation, and Ex vivo Evaluation of Solid Lipid Nanoparticles for Transdermal Delivery of Diltiazem Hydrochloride.
Pharm Nanotechnol
October 2024
ISF College of Pharmacy, department of pharmaceutics, Moga, Punjab 142001, India.
Article Synopsis
- The study addresses cardiac arrhythmias, a condition requiring long-term management with medications like diltiazem hydrochloride, which faces limitations in traditional administration methods due to absorption challenges.
- Researchers developed a transdermal patch using solid lipid nanoparticles (SLNs) to enhance the drug's skin permeability and bioavailability, employing a solvent diffusion technique for SLN preparation.
- Results showed that the formulated patch had a good drug release profile (70.7% over 24 hours), a high drug content of 89.37%, and an optimal surface pH close to that of human skin, making it a promising delivery method for diltiazem.
Evaluation and comparison of autologous particulate dentin with demineralized freeze dried bone allograft in ridge preservation procedures - a prospective clinical study.
Clin Oral Investig
August 2024
Department of Periodontics and Implantology, Vishnu dental college, Vishnupur, Bhimavaram, West Godavari, West Godavari, Andhra Pradesh, 534202, India.
Article Synopsis
- The study aimed to compare the effectiveness of Autologous Particulate Dentin (APD) and Demineralized Freeze-Dried Bone Allograft (DFDBA) in preserving jawbone ridges after tooth extraction, analyzing both clinical and radiographic outcomes.
- Thirty participants had their mandibular posterior teeth extracted and were divided into two groups to receive either APD or DFDBA mixed with i-PRF, with assessments conducted before and six months after the procedure.
- Results showed that while both groups experienced a decrease in ridge dimensions, the APD group had less reduction in horizontal ridge width compared to the DFDBA group, indicating APD may be a more effective option for ridge preservation.
Horizontal ridge augmentation using guided bone regeneration with an association of particulate allografts mixed with platelet-rich fibrin, collagen membrane and tent-screws: A prospective study.
J Stomatol Oral Maxillofac Surg
September 2024
Oral and Maxillofacial Surgery Department, Université libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), HUB Hôpital Erasme, 808 route de Lennik, B-1070, Bruxelles, Belgium.
Background: Guided Bone Regeneration (GBR) is a versatile technique employed not only to correct pre-implant alveolar bone defects but also to facilitate bone defect correction during simultaneous implant placement. The effectiveness of GBR varies significantly among different protocols, as reported in the literature. This study specifically aimed to radiologically evaluate the horizontal bone gain obtained using a GBR procedure combining a particulate allograft, platelet-rich fibrin, resorbable collagen membrane, and screw tents.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!