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Phosphorylation, disorder, and phase separation govern the behavior of Frequency in the fungal circadian clock.
Elife
March 2024
Department of Chemistry & Chemical Biology, Cornell University, Ithaca, United States.
Circadian clocks are composed of transcription-translation negative feedback loops that pace rhythms of gene expression to the diurnal cycle. In the filamentous fungus the proteins requency (RQ), the RQ-interacting RNA helicase (FRH), and asein-Kinase I (CK1) form the complex that represses expression of genes activated by the white-collar complex (WCC). FRQ orchestrates key molecular interactions of the clock despite containing little predicted tertiary structure.
View Article and Find Full Text PDFIncidence trends of adult glioma in Norway and its association with occupation and education: A registry-based cohort study.
Cancer Epidemiol
April 2024
Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway; Cancer Registry of Norway, Oslo, Norway.
Background: Gliomas constitute 75 % of all malignant primary adult brain tumors. Being the most frequent histologic subtype, glioblastomas (GBMs) cause substantial morbidity and mortality worldwide and the Nordic countries have some of the highest incidence rates in the world. Therefore, we investigated the incidence of gliomas in Norway including time trends and associations with education and occupation.
View Article and Find Full Text PDFIdentifying depression and its determinants upon initiating treatment: ChatGPT versus primary care physicians.
Fam Med Community Health
September 2023
Department of Psychology and Educational Counseling, Max Stern Academic College Of Emek Yezreel, Emek Yezreel, Israel.
Objective: To compare evaluations of depressive episodes and suggested treatment protocols generated by Chat Generative Pretrained Transformer (ChatGPT)-3 and ChatGPT-4 with the recommendations of primary care physicians.
Methods: Vignettes were input to the ChatGPT interface. These vignettes focused primarily on hypothetical patients with symptoms of depression during initial consultations.
Work addiction in Chinese white-collar workers: the psychometric properties of its measure and its comorbidity with general anxiety in network analysis.
BMC Psychol
July 2023
Department of Psychology, Faculty of Social Sciences, University of Macau, Avenida da Universidade, Taipa, Macao SAR, China.
Background: Work addiction (WA) threatens occupation-related health in many countries including China. This research aims to evaluate the psychometric properties of the Chinese version of Bergen Work Addiction Scale (BWAS), the most common measure of WA, to facilitate relevant studies in Chinese workers. A network analysis was further conducted to identify central and bridge symptoms within the WA-anxiety network to improve intervention practices.
View Article and Find Full Text PDFHaving the right face for the job: The effect of facial width-to-height ratio on job selection preferences.
Br J Soc Psychol
April 2023
Department of Brain and Psychological Sciences, Indiana University, Bloomington, Indiana, USA.
Prior research has found that various job candidate characteristics can influence hiring decisions. The current work used experimental methods to test how a novel, appearance-based cue known as a facial width-to-height ratio (fWHR) can bias hiring preferences. A first study provides evidence for our initial hypothesis: people believed high fWHR candidates would be a better fit for blue-collar jobs compared with low fWHR candidates, who were in turn favoured for white-collar jobs.
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