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The impact of ciliary length on the mechanical response of osteocytes to fluid shear stress.
Nitric Oxide
December 2024
Key Laboratory for Biomechanics and Mechanobiology, Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100191, China. Electronic address:
Background: Osteocytes are crucial for detecting mechanical stimuli and translating them into biochemical responses within the bone. The primary cilium, a cellular 'antenna,' plays a vital role in this process. However, there is a lack of direct correlation between cilium length changes and osteocyte mechanosensitivity changes.
View Article and Find Full Text PDFChloral hydrate is a hypnotic, sedative and anxiolytic (non-benzodiazepine) drug that is commonly administered to children prior to procedures such as dental sedation. It is also indicated for nocturnal sedation in all types of patients and especially for the ill, the young, and the elderly patients. A review of the therapeutic uses of chloral hydrate reveals the need for flexibility in dosing, especially in children.
View Article and Find Full Text PDFThe Application of Sleep Deprivation Combined With Chloral Hydrate on Pediatric Dermatological Surgery.
Dermatol Surg
November 2024
Department of Dermatology, Second Affiliated Hospital of Xi'an Jiaotong University, Shaanxi, Xi'an.
Background: In small dermatological surgeries for infant and child patients, it is required that the child be in a quiet state. However, general anesthesia not only requires the participation of professional anesthesiologists for surgery but also has a high cost and anesthesia risks. Parents have a low acceptance rate.
View Article and Find Full Text PDFAnesthetic effects on electrophysiological responses across the visual pathway.
Sci Rep
November 2024
Institute of Visual Neuroscience and Stem Cell Engineering, Wuhan University of Science and Technology, Wuhan, 430065, China.
Anesthetics are widely used in electrophysiological tests to assess retinal and visual system functions to avoid experimental errors caused by movement and stress in experimental animals. To determine the most suitable anesthetic for visual electrophysiological tests, excluding ketamine and chloral hydrate due to regulatory and side effect concerns, this study investigated the effects of ethyl carbamate (EC), avertin (AR), and pentobarbital sodium (PS) on visual signal conduction in the retina and primary visual cortex. Assessments included flash electroretinogram (FERG), pattern electroretinogram (PERG), pattern visual evoked potentials (PVEP), and flash visual evoked potentials (FVEP), FERG and FVEP were used to evaluate the responses of the retina and visual cortex to flash stimuli, respectively, while PERG and PVEP assessed responses to pattern stimuli.
View Article and Find Full Text PDFIncidence and risk factors of prolonged recovery during procedural sedation in pediatrics.
Front Med (Lausanne)
October 2024
Department of Anesthesiology, The Affiliated Hospital, School of Medicine, UESTC Chengdu Women's & Children's Central Hospital, Chengdu, China.
Article Synopsis
- The study analyzed sedation data from pediatric patients over two years to identify risk factors for prolonged recovery during procedural sedation, as current literature lacks this information.
- A total of 30,003 pediatric patients were reviewed, with 854 (2.8%) experiencing prolonged recovery, relating to factors such as body weight, being an outpatient, previous sedation history, and receiving chloral hydrate.
- The findings suggest that monitoring time should be increased for patients with these specific risk factors to enhance safety and procedural efficiency.
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