AI Article Synopsis
- - A patient exhibited generalized malignant acanthosis nigricans for 2 years without any symptoms, which usually indicates an underlying internal malignancy.
- - Extensive medical tests showed that the patient had widespread metastasis of mucin-secreting signet cell adenocarcinoma from an unknown primary source.
- - The patient also displayed other skin conditions, including acquired hypertrichosis lanuginose and cutaneous papillomatosis, which can also signal internal malignancies.
Article Abstract
A case of generalized malignant acanthosis nigricans of 2 years duration is reported. In spite of the long duration of this cutaneous marker of internal malignancy, the patient was completely asymptomatic and extensive investigations revealed the presence of widespread metastasis of mucin secreting signet cell adenocarcinoma from an unknown primary site. In addition the patient also had acquired hypertrichosis lanuginose and florid cutaneous papillomatosis which are also markers of internal malignancy.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Vulvar Epidermolytic Hyperkeratosis: A Comprehensive Systematic Review of Case Reports and Series.
J Clin Med
December 2024
Department of Oncologic Dermatology-Elias Emergency University Hospital, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
: Vulvar epidermolytic hyperkeratosis (EHK) is an exceedingly rare dermatological condition, often presenting as solitary or multiple lesions in the vulvar region. Due to its clinical resemblance to other vulvar disorders, such as condyloma acuminatum, Bowenoid papulosis, and squamous cell carcinoma, vulvar EHK poses significant diagnostic challenges. While individual case reports and small case series have documented instances of vulvar EHK, comprehensive studies systematically consolidating the clinical, histopathological, and therapeutic aspects of this condition remain lacking.
View Article and Find Full Text PDFMalignant Acanthosis Nigricans as a Dermatological Indicator of Gastric Adenocarcinoma: A Case Report.
QJM
January 2025
Department of Dermatology, Dalian Dermatosis Hospital, Dalian, Liaoning, 116011, China.
Large Nevus Lipomatosus Cutaneous Superficialis in the Skin of Color.
Skinmed
January 2025
Division of Dermatology, Department of Medicine, Albert Einstein College of Medicine, Montefiore Hospital, Bronx, NY.
A 15-year-old African-American man (Fitzpatrick skin type V) presented to the outpatient dermatology clinic with a large, verrucous, exophytic mass measuring 3.5 × 2.3 cm on the right lateral side of the posterior flank (Figure 1).
View Article and Find Full Text PDFSkin as a Reflection of Gut Health: An Overview of Dermatological Manifestations in Primary Neoplastic and Autoimmune Gastrointestinal Disorders.
Cureus
October 2024
Internal Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK.
Gastrointestinal (GI) diseases can present with several extraintestinal manifestations, and cutaneous signs and symptoms are most frequent. Although conventionally GI and skin are considered two entirely separate organ systems, they are closely correlated in origin. An increasing amount of data highlights the complex relationship between GI and dermatological conditions.
View Article and Find Full Text PDFPrecancerous Lesions of HPV-independent Vulvar Squamous Cell Carcinoma: Clinicopathologic Consideration of an Evolving Spectrum.
Adv Anat Pathol
January 2025
Department of Pathology, University of California San Diego, San Diego, CA.
Article Synopsis
- HPV-independent squamous cell carcinomas are the most common type of vulvar cancer, but their precancerous lesions are infrequently seen in clinical practice.
- Differentiated vulvar intraepithelial neoplasia (dVIN) is the main precancerous lesion associated with a high risk of progression and is often linked to lichen sclerosus, with a significant number showing TP53/p53 abnormalities.
- The review discusses various related lesions and emphasizes updates in terminology, diagnostics, biomarkers, and the underlying processes of these precancerous conditions.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!