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The authors aim to highlight the pitfalls of different validated methods used for the assessment of drugs' effect on QT duration. Digital 12-lead Holter electrocardiograms were recorded at baseline and after a single dose of sotalol in 39 healthy subjects (age = 27.4 +/- 8.0 years). Using both time- and rate-based approaches, the authors obtained averaged QRS-T complexes every minute ("time bins") and at different RR intervals ("rate bins"). Time bins were corrected for heart rate using a subject-specific approach. The individual alpha coefficients increased from placebo (0.309 +/- 0.052) to sotalol (0.454 +/- 0.136), P < .0001. When the placebo individual alpha coefficients were applied to correct the QT interval on sotalol, the changes were >5 ms smaller than those obtained using the ON drug alpha coefficients. The "rate"-averaging process leads to a complete loss of the time course of drug effect. In conclusion, the individual correction formula calculated from the placebo condition cannot always be used for QT correction on the drug.
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http://dx.doi.org/10.1177/0091270007302953 | DOI Listing |
BMC Nurs
December 2024
School of Nursing, Chengdu University of Traditional Chinese Medicine, No. 1166 Liutai Road, Wenjiang District, Chengdu city, Sichuan Province, 611137, China.
Background: Psychological capital (PsyCap) is a positive internal resource for individuals, playing a crucial role in mental health. Evaluating nurses' psychological capital is important for understanding their mental well-being, as they face unique occupational stressors. However, existing PsyCap questionnaires are developed for various other professions such as enterprise employees, teachers, patients, teenagers, and civil servants, making them less suitable for the nursing profession.
View Article and Find Full Text PDFBMC Health Serv Res
December 2024
Environmental and Occupational Hazards Control Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tabnak Ave., Daneshjou Blvd., Velenjak, P.O. Box 19835-35511, Tehran, I.R, Iran.
Background: Toward delivering appropriately safe, high quality and effective health care, healthcare organization should be health literate. This paper presents the development and psychometrics of an instrument for assessing the attributes of a health literate hospital which is called MAHLO-76 (Measure to Assess Health Literate Organization) here by authors.
Methods: The current study is methodological research which is involved two phases of tool development and psychometric evaluation.
BMC Palliat Care
December 2024
National Cancer Survivorship Center, National Cancer Control Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang-si Gyeonggi-do, 10408, Republic of Korea.
Background: The Integrated Palliative care Outcome Scale (IPOS) is a key tool for assessing the quality of palliative care using patient-reported outcomes. This study aimed to culturally adapt and translate the IPOS to Korean and verify its psychometric properties for use in palliative care settings.
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BMC Med Educ
December 2024
Center for Health Related Social and Behavioral Sciences Research, Shahroud University of Medical Sciences, Shahroud, Iran.
Background: This study aimed to evaluate the psychometric properties of the Persian version of the Study Anxiety Questionnaire (SAQ).
Methods: This methodological study was conducted in 2024 among 380 medical sciences students at Shahroud University of Medical Sciences, Iran. The face and content validity of the questionnaire were assessed using both quantitative and qualitative approaches following a forward-backward translation process.
Obes Rev
December 2024
Department of Nursing, School of Health and Welfare, Jönköping University, Hälsohögskolan, Jönköping, Sweden.
Food addiction (FA) is linked to eating disorders and obesity. The Yale Food Addiction Scale (YFAS), which has various versions in different languages, is widely used to assess FA worldwide. This meta-analysis aimed to assess the YFAS through reliability generalization meta-analysis (REGEMA).
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