Ranula and HIV: an explanation of their relationship.

J Oral Maxillofac Surg

Published: August 2007

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http://dx.doi.org/10.1016/j.joms.2007.02.007DOI Listing

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Article Synopsis
  • - Oral symptoms can be early signs of HIV, with conditions like oral candidiasis and hairy leukoplakia being strongly linked to the virus.
  • - While ranulas occur due to salivary leakage from gland obstruction, there's no proven connection between this condition and HIV.
  • - A case study showcased a successful surgical removal of a plunging ranula in a patient with HIV, emphasizing the need for detailed patient history and strict safety practices during surgery.
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A plunging ranula is a benign cystic lesion in the neck formed due to mucin extravasated from a salivary gland, most commonly the sublingual gland. Ranulas have been described in association with congenital anomalies, trauma, diseases of the sublingual gland, and HIV; however, rarely, they may result as a complication of various oral and neck surgeries. Here, we report a rare case of plunging ranula that developed in an elderly male as a sequalae to surgery for tongue cancer.

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Ranula as the First Symptom of HIV Infection in Young Patients.

Case Rep Pediatr

June 2021

Department of Stomatology and Maxillofacial Surgery, Université Libre de Bruxelles (ULB), CHU-Saint-Pierre, Rue Haute 322, Brussels 1000, Belgium.

Introduction: Oral manifestations are often the earliest HIV signs. Salivary gland diseases are a common form of HIV expression. A ranula can occur in association with HIV.

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Treatment of oral ranula in HIV-positive patient.

Auris Nasus Larynx

February 2021

Division of Otolaryngology, Tohoku Medical and Pharmaceutical University, Sendai 981-0905, Japan. Electronic address:

Article Synopsis
  • HIV-associated salivary gland disease includes conditions like ranula and salivary gland swelling, often seen in patients with HIV.
  • The case study highlights a 42-year-old Japanese male with a ranula who was also found to be HIV-positive, diagnosed through standard clinical examination.
  • Treatment with OK-432 sclerotherapy successfully eliminated the ranula, suggesting it as an effective option for managing this condition in HIV-infected patients.
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Article Synopsis
  • The study looked at how to best treat a condition called plunging ranula by removing the sublingual gland from inside the mouth.
  • Most of the patients were adults with HIV, and the surgery had a good success rate, with no complications or regrowth of the ranula.
  • The researchers concluded that taking out the gland through the mouth is the best way to handle this problem without needing extra cuts or drains.
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