Introduction: Superwarfarins are widely used as rodenticides. They are similar to warfarin, but they are more potent and act longer. In case of poisoning, they cause severe bleeding, usually from multiple sites.
Case Report: A 67-yr-old man was admitted with melaena, epistaxis and haemarthrosis in his left knee. PT, INR and aPTT were markedly increased. Initially, the patient was treated with blood and fresh frozen plasma (FFP) transfusions. However at the second day, PT, INR and aPTT were even worse. The combination of persistent coagulopathy, normal mixing studies, normal liver function tests and absence of hepatic failure or malabsorption syndromes lead to the suspicion of vitK dependent clotting factors deficiency due to superwarfarin poisoning. Indeed, the patient admitted a suicide attempt with rodenticide, although he had previously denied it. Psychiatric evaluation revealed a disturbed personality. Melaena stopped after 7 d. Then, the patient was administered 30 mg of vitK daily for a total period of 4 months.
Conclusions: Superwarfarin poisoning leads to severe bleeding, usually from multiple sites. Prolonged treatment with high doses of vitK is necessary. Haemarthrosis, as a complication of superwarfarin poisoning, is presented here for the first time in literature.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1600-0609.2007.00904.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Acute long-acting anticoagulant rodenticide poisoning in pregnancy: a case report.
Front Pharmacol
November 2024
Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- Brodifacoum is a highly effective rodent poison that can cause serious bleeding issues (coagulopathy), but its effects during pregnancy are not well documented.
- A case study reported a pregnant woman experiencing severe bleeding due to brodifacoum poisoning, leading to serious complications and the loss of the fetus.
- Effective management of brodifacoum poisoning is essential, with timely recognition and treatment (like vitamin K1) needed to improve outcomes for pregnant patients.
Systematic forensic identification of a homicide by brodifacoum poisoning: A case report.
J Forensic Leg Med
November 2024
Department of Forensic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address:
Brodifacoum, a long-acting anticoagulant rodenticide, exerts inhibitory effects on blood coagulation factor synthesis, leading to abnormal clotting function and potential fatality. Poisoning of accidental exposure to brodifacoum is not rare, but death from brodifacoum poisoning can be largely avoided with timely and long-term effective treatments, consequently, forensic data on fatalities due to brodifacoum poisoning may be limited. This paper presents a case of brodifacoum-induced homicide, detailing the medial records and pathological changes observed in multiple organs.
View Article and Find Full Text PDFDeploying Validated Mass Spectrometry for Frontline Detection and Treatment of Human Poisoning by Long-Acting Anticoagulant Rodenticides.
Chem Res Toxicol
November 2024
Jesse Brown VA Medical Center and Department of Anesthesiology, University of Illinois College of Medicine in Chicago, Chicago, Illinois 60612, United States.
Article Synopsis
- * LAARs can cause severe bleeding (coagulopathy) in humans if blood levels exceed 10 ng/mL, leading to numerous poisonings each year.
- * Various analytical methods, mainly using liquid chromatography-mass spectrometry (LC-MS), have been developed to quickly identify and analyze LAARs in patients experiencing severe bleeding, and these methods are evaluated for their validation and clinical utility.
Second-Generation Anticoagulant Rodenticide Toxicosis in a Wild Carnaby's Cockatoo ().
J Avian Med Surg
October 2024
School of Veterinary Medicine, Murdoch University, Murdoch, Western Australia 6151, Australia.
Article Synopsis
- * On Day 4, the bird experienced severe bleeding, nosebleeds, and anemia, leading to its euthanasia due to ongoing health decline.
- * Testing revealed high levels of anticoagulant rodenticides in its liver, marking the first recorded case of rodenticide poisoning in this wild Australian bird species.
Widespread use of anticoagulant rodenticides in agricultural and urban environments. A menace to the viability of the endangered Bonelli's eagle (Aquila fasciata) populations.
Environ Pollut
October 2024
Service of Toxicology and Forensic Veterinary Medicine, Department of Health Sciences, Faculty of Veterinary Medicine, Campus de Espinardo, Universidad de Murcia, 30100, Murcia, Spain; Toxicology and Risk Assessment Research Group, IMIB-Pascual Parrilla, University of Murcia, 30120 El Palmar, Spain.
Article Synopsis
- * A study analyzed 17 Bonelli's eagle carcasses in Eastern Spain, finding that all had been exposed to at least 5 of the 10 ARs tested, with second generation ARs being the most common.
- * The significant presence of ARs in these eagles, along with liver concentrations suggesting potential poisoning, raises concerns about their impact on the eagle population and associated risks to public health due to the diet of these birds.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!