Microwave tomographic imaging falls under a broad category of nonlinear parameter estimation methods when a Gauss-Newton iterative reconstruction technique is used. A fundamental requirement in using these approaches is evaluating the appropriateness of the regression model. While there have been numerous investigations of regularization techniques to improve overall image quality, few, if any, studies have explored the underlying statistical properties of the model itself. The ordinary least squares (OLS) approach is used most often, but there are other options such as the weighted least squares (WLS), maximum likelihood (ML), and maximum a posteriori (MAP) that may be more appropriate. In addition, a number of variance stabilizing transformations can be applied to make the inversion intrinsically more linear. In this paper, a statistical analysis is performed of the properties of the residual errors from the reconstructed images utilizing actual measured data and it is demonstrated that the OLS algorithm with a log transformation (OLSlog) is clearly advantageous relative to the more commonly used OLS approach by itself. In addition, several high contrast imaging experiments are performed, which demonstrate that different subsets of data are emphasized in each method and may contribute to the overall image quality differences.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1118/1.2737264 | DOI Listing |
Food Addit Contam Part A Chem Anal Control Expo Risk Assess
January 2025
Retired, Office of Public Health Science, USDA FSIS, Fort Collins, CO, USA.
Plasma, milk and tissue samples were collected from 30 dairy cattle (0.4 to 8.9 years of age) with lifetime exposures to perfluoroalkyl substances (PFAS) removed from a PFAS-contaminated farm and provided PFAS-free feed and water.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Turner Institute for Brain and Mental Health & School of Psychological Sciences, Monash University, Clayton, VIC, Australia
Background: Plasma and cerebrospinal (CSF) biomarkers are promising candidates for detecting neuropathology. While CSF biomarkers directly reflect pathophysiological processes within the central nervous system, their requirement for a lumbar puncture is a barrier to their widespread scalability in practice. Therefore, we examined cross‐sectional associations of plasma biomarkers of amyloid (Aβ42/Aβ40 and pTau‐181), neurodegeneration (Neurofilament Light, NfL), and neuroinflammation (Glial Fibrillary Acidic Protein, GFAP) with brain volume, cognition, and their corresponding CSF levels.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
The Mind Research Network, Albuquerque, NM, USA
Background: In recent efforts to improve early identification, staging, and prediction of risk of persons at risk for vascular contributions to cognitive impairment and dementia (VCID) in relation with small vessel disease (SVD), the MarkVCID consortium has worked to identify and validate fluid‐ and imaging‐based biomarkers for SVD associated with VCID. Free water (FW) measured derived from diffusion tensor imaging and one of the selected neuroimaging biomarker “kits”, has been demonstrated to have excellent instrumental validity and to be a sensitive biomarker of cognitive performances. We sought to further examine FW clinical relevance by investigating whether FW predicts cognitive worsening over time.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Background: Plasma tau phosphorylated at threonine 231 (p‐tau231) is a promising novel biomarker of emerging Alzheimer's disease (AD) pathology. We aimed to characterize cross‐sectional and longitudinal plasma p‐tau231 measurements and estimated ages of biomarker onset in an exceptionally large number of presenilin (PSEN1) E280A (Glu280Ala) mutation carriers and age‐matched non‐carriers from the Colombian autosomal dominant Alzheimer’s disease kindred.
Method: We included a cohort of 722 PSEN1 E280A mutation carriers (mean age 36.
Alzheimers Dement
December 2024
Centre for Brain Research, University of Auckland, Auckland, New Zealand
Background: Single molecule array (Simoa) technology enables the detection of Alzheimer’s disease (AD) neuropathology in blood. This study compared cross‐sectional biomarker profiles for participants from the New Zealand‐Dementia Prevention Research Clinics (NZ‐DPRCs) who spanned the continuum from healthy older adults to a clinical diagnosis of AD.
Method: NZ‐DPRC participants were clinically classified as cognitively unimpaired adults (CU, n=34), subjective cognitive decline (SCD, n=65), non‐amnestic mild cognitive impairment (single and multi‐domain, non‐aMCI, n= 23), amnestic MCI (single and multi‐domain, aMCI, n=104), and AD (n=27).
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!