An in-frame deletion of the yopH gene in Yersinia pestis CO92 attenuates virulence in both bubonic and pneumonic plague models. When it is used as a live, attenuated vaccine, CO92 delta yopH provides a high degree of protection from parental and respiratory challenge with Y. pestis CO92.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043315 | PMC |
| http://dx.doi.org/10.1128/CVI.00137-07 | DOI Listing |
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