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Conformational diversity in class C GPCR positive allosteric modulation.
Nat Commun
January 2025
IGF, Université de Montpellier, CNRS, INSERM, 34094, Montpellier, France.
The metabotropic glutamate receptors (mGlus) are class C G protein-coupled receptors (GPCR) that form obligate dimers activated by the major excitatory neurotransmitter L-glutamate. The architecture of mGlu receptor comprises an extracellular Venus-Fly Trap domain (VFT) connected to the transmembrane domain (7TM) through a Cysteine-Rich Domain (CRD). The binding of L-glutamate in the VFTs and subsequent conformational change results in the signal being transmitted to the 7TM inducing G protein binding and activation.
View Article and Find Full Text PDFThe emerging landscape and future perspective of SCLC transformation: from molecular mechanisms to therapeutic strategies.
Crit Rev Oncol Hematol
January 2025
Department of Internal Medicine-Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. Electronic address:
Small-cell lung cancer (SCLC) is featured by high malignancy and undesirable prognosis. Transformed SCLC shares several common grounds but differ in biological behavior, molecular mechanism and therapeutic options from typical SCLC. SCLC transformation exerts indispensable role in drug resistance among patients with non-small cell lung cancer (NSCLC) upon various treatment modalities.
View Article and Find Full Text PDFA qualitative study exploring the feasibility and acceptability of embedding an overdose prevention sites in a U.S. hospital.
J Subst Use Addict Treat
January 2025
University of Pennsylvania School of Nursing, Philadelphia, PA, USA.
Introduction: Community-based overdose prevention sites (OPS) are recognized for reducing overdose deaths and the spread of HIV and hepatitis C among people who use drugs (PWUD). While some hospitals in Europe and Canada have successfully integrated OPS into their facilities, such integration remains illegal in the United States. This study explores the feasibility and acceptability of implementing an OPS at the Hospital of the University of Pennsylvania (HUP), situated in an urban area with high rates of overdose.
View Article and Find Full Text PDFInsights into eye genetics and recent advances in ocular gene therapy.
Mol Cell Probes
January 2025
Institute of Molecular and Clinical Ophthalmology Basel, Basel, Switzerland, Mittlere Strasse 91, CH-4031. Electronic address:
The rapid advancements in the field of genetics have significantly propelled the development of gene therapies, paving the way for innovative treatments of various hereditary disorders. This review focuses on the genetics of ophthalmologic conditions, highlighting the currently approved ophthalmic gene therapy and exploring emerging therapeutic strategies under development. Inherited retinal dystrophies represent a heterogeneous group of genetic disorders that manifest across a broad spectrum from infancy to late middle age.
View Article and Find Full Text PDFRelative fire-proneness of land cover types in the Brazilian Atlantic forest.
J Environ Manage
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CE3C-Centre for Ecology, Evolution and Environmental Changes & CHANGE, Global Change and Sustainability Institute, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, C2, Piso 5, 1749-016, Lisboa, Portugal. Electronic address:
Fires are increasingly affecting tropical biomes, where landscape-fire interactions remain understudied. We investigate the fire-proneness-the likelihood of a land use or land cover (LULC) type burning more or less than expected based on availability-in the Brazilian Atlantic Forest (AF). This biodiversity hotspot is increasingly affected by fires due to human activities and climate change.
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