AI Article Synopsis
- The study investigates the use of proPSA and free PSA in improving the preoperative staging and grading of prostate cancer (PCa) in patients undergoing radical prostatectomy.
- It analyzes serum samples from 376 PCa patients, finding that proPSA levels were significantly different between certain stages and grades of the disease, especially in patients with lower free PSA percentages.
- The conclusion suggests that while proPSA alone wasn't effective in detecting aggressive PCa, the proPSA/% free PSA ratio provided better differentiation in staging and grading across various PSA levels.
Article Abstract
Background: ProPSA has been suggested for the detection of preferentially aggressive prostate cancer (PCa). We report on the use of proPSA and free PSA to enhance preoperative staging and grading.
Patients And Methods: Serum samples from 376 PCa patients within the PSA range 1-25 microg/l who underwent radical prostatectomy were analysed for PSA, free PSA (fPSA) and (-5, -7) proPSA.
Results: ProPSA was only significantly different between pT2 and pT3 PCa (p = 0.02) in the subgroup of patients with % fPSA < 10%. The ratio proPSA/% fPSA differed between G2 and G3 (p = 0.004), Gleason < 7 and Gleason > or =7 (p = 0.001), and pT2 and pT3 tumors (p < 0.0001) at PSA 1-25 microg/l. However, % fPSA improved differentiation only between Gleason < 7 and Gleason > or = 7 tumors, not between pT2 and pT3 or G2 and G3 tumors.
Conclusion: ProPSA as a single parameter did not improve the detection of non-organ confined or aggressive PCa whereas proPSA/% fPSA further improved staging and grading within all analysed PSA ranges.
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