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Porcine Nose Atrophy Assessed by Automatic Imaging and Detection of and Other Respiratory Pathogens in Lung and Nose.
Animals (Basel)
October 2024
Field Station for Epidemiology, University of Veterinary Medicine Hannover, Foundation, 49456 Bakum, Germany.
The nasal mucosa is a crucial filtering organ to prevent attachment and invasion of pathogens. To assess nasal health in relation to lung health, transverse cross sections of the nasal turbinates of 121 pigs suffering from respiratory disease and sent for diagnostic necropsy were scored visually and by an artificial intelligence (AI) medical diagnostic application (AI DIAGNOS), resulting in a high correlation of both scores ( < 0.001).
View Article and Find Full Text PDFDevelopment of a New Swine Model Resembling Human Empty Nose Syndrome.
Medicina (Kaunas)
September 2024
Department of Otolaryngology-Head and Neck Surgery, Seoul Saint Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Empty nose syndrome (ENS) is a debilitating condition that often results from traumatic or iatrogenic causes, such as nasal surgery. There are various conservative and surgical treatments for ENS, but their effectiveness remains uncertain. Therefore, the development of animal models that accurately mimic human ENS is essential for advancing effective treatment strategies.
View Article and Find Full Text PDFRevealing the lethal effects of toxin on multiple organ systems.
Front Microbiol
August 2024
Research Center for Swine Diseases, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Article Synopsis
- PMT (Pasteurella multocida toxin) is a major virulence factor in type D infections, leading to significant economic losses in pig farming and severe organ damage in both pigs and mice.
- The study found that PMT is highly cytotoxic, particularly affecting the kidneys and lungs, with even low doses causing weight loss and higher doses resulting in acute death in both mice and pigs.
- Pathological analysis revealed severe organ damage, including hemorrhage in the lungs and liver, and desolation of the kidneys, highlighting PMT's extreme toxicity and its impact on vital organs.
Article Synopsis
- This study investigates how network pharmacology and molecular docking can help predict the effects of active components from oil tree peony seed meal (PSM) on various diseases affecting swine.
- Ten active components from PSM were identified, and a list of ten swine diseases was selected for analysis, including African Swine Fever and Swine Influenza.
- The findings revealed key target genes and pathways related to swine diseases, highlighting eight core targets involved in crucial cellular processes and potential interactions with the identified active components.
Intranasal administration of a synthetic TLR4 agonist INI-2004 significantly reduces allergy symptoms following therapeutic administration in a murine model of allergic sensitization.
Front Immunol
August 2024
Inimmune Corporation, Missoula, MT, United States.
Introduction: Atopic diseases have been steadily increasing over the past decades and effective disease-modifying treatment options are urgently needed. These studies introduce a novel synthetic Toll-like receptor 4 (TLR4) agonist, INI-2004, with remarkable efficacy as a therapeutic intranasal treatment for seasonal allergic rhinitis.
Methods: Using a murine airway allergic sensitization model, the impact of INI-2004 on allergic responses was assessed.
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