The Bipolar Disorder in infants and youngsters is not very known and under-diagnosed in the concerned population. We hereby describe its clinical features, its comorbidity along with other frequent psychopathologies, such as ADHD, which enable us to describe the symptoms and the indicators of risk. According to how these indicators appear, we can establish various degrees of clinical risk. Irritability, impulsiveness, hyperactivity, intolerance to frustration and sleep disorders are the most frequent prodroms. If they present a clinic of suicidality, toxic abuse (cannabis, alcohol), or even psychotic symptoms, in the context of significant family history, the child psychiatrist should not doubt to diagnose Bipolar Disorder and start the corresponding treatment.
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Nature
January 2025
Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.
View Article and Find Full Text PDFTransl Psychiatry
January 2025
Department of Radiology, and Functional and Molecular Imaging Key Laboratory of Sichuan Province, West China Hospital of Sichuan University, Chengdu, China.
Despite observational studies linking brain iron levels to psychiatric disorders, the exact causal relationship remains poorly understood. This study aims to examine the relationship between iron levels in specific subcortical brain regions and the risk of psychiatric disorders. Utilizing two-sample Mendelian randomization (MR) analysis, this study investigates the causal associations between iron level changes in 16 subcortical nuclei and eight major psychiatric disorders, including schizophrenia (SCZ), major depressive disorder (MDD), autism spectrum disorders (ASD), attention-deficit/hyperactivity disorder, bipolar disorder, anxiety disorders, obsessive-compulsive disorder, and insomnia.
View Article and Find Full Text PDFJ Neurophysiol
January 2025
Department of Family Medicine, Cumming School of Medicine; University of Calgary; Calgary, Alberta, T2N 1N4; Canada.
Stress is a fundamental adaptive response mediated by the amygdala and Hypothalamus-Pituitary-Adrenal (HPA) axis. Extreme or chronic stress, however, can result in a multitude of neuropsychiatric disorders, including anxiety, paranoia, bipolar disorder (BP), major depressive disorder (MDD), and Post-Traumatic Stress Disorder (PTSD). Despite widespread exposure to trauma (70.
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