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Influence of cadmium ion on denaturation kinetics of hen egg white-lysozyme under thermal and acidic conditions.
Spectrochim Acta A Mol Biomol Spectrosc
August 2023
Department of Chemical Physics, University of Science and Technology of China, Hefei 230026, China. Electronic address:
Article Synopsis
- The study investigates how Cd(II) ions affect the denaturation kinetics of hen egg white lysozyme (HEWL) using various spectroscopy and imaging techniques.
- It identifies four key Raman spectral markers to track changes in protein structure, showing that Cd(II) ions accelerate the transformation of the protein's tertiary structure while facilitating the direct formation of organized β-sheets from α-helices.
- The research demonstrates that Cd(II) ions lead to the formation of disordered oligomers that aggregate into gel-like structures rather than traditional amyloid fibrils, revealing unique ion-specific effects on protein denaturation pathways.
Force can modulate the properties and functions of macromolecules by inducing conformational changes, such as coiling/uncoiling, zipping/unzipping, and folding/unfolding. Here we compared force-modulated bending/unbending of two purified integrin ectodomains, α β and α β , using single-molecule approaches. Similar to previously characterized mechano-sensitive macromolecules, the conformation of α β is determined by a threshold head-to-tail tension, suggesting a canonical energy landscape with a deep energy well that traps the integrin in the bent state until sufficient force tilts the energy landscape to accelerate transition to the extended state.
View Article and Find Full Text PDFA Novel Polydopamine Grafted 3D MOF Nanocubes Mediated GR-5/GC DNAzyme Complex with Enhanced Fluorescence Emission Response toward Spontaneous Detection of Pb(II) and Ag(I) Ions.
ACS Omega
October 2020
Department of Chemistry, SRM Institute of Science and Technology, Kattankulathur 603 203, Tamil Nadu, India.
In this work, we have proposed a novel DNAzyme/MnCoPBAs-PDANCs complex-based fluorescence biosensor for subsequent detection of Pb and Ag ions. The GR-5/GC-rich DNAzymes are strongly anchored or quenched on the surface of polydopamine hybridized 3D metal-organic framework MnCoPBAs-PDANCs by π-π stacking interaction. Addition of Pb ions has exhibited a catalytic inner cleavage of DNAzyme complex and disturbs to release shorter GC-rich sequence over the surface of MnCoPBAs-PDANCs complexes.
View Article and Find Full Text PDFUncoiling of helical boron nitride-graphene nanoribbons in a single-walled carbon nanotube.
Phys Chem Chem Phys
January 2017
Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan, 250061, People's Republic of China.
Molecular dynamics simulation has been employed to study the encapsulation of boron nitride-graphene nanoribbons (BNCNRs) in a single-walled carbon nanotube (SWNT). The simulation results show that a helical BNCNR with large curvature can uncoil repeatedly and spontaneously in the SWNT, like the unwinding of the DNA in the nucleus. The uncoiling of the BNCNRs is accompanied by a system energy exchange between non-bonding energy and elastic potential energy due to the competition between the induction of graphene nanoribbon (GNR) segments and the resistance of boron nitride nanoribbon (BNNR) segments.
View Article and Find Full Text PDFWe report a new approach to obtaining single-transverse-mode operation of a multimode fiber amplifier in which the gain fiber is coiled to induce significant bend loss for all but the lowest-order mode. We demonstrated this method by constructing a coiled amplifier using Yb-doped, double-clad fiber with a core diameter of 25 microm and a numerical aperture of ~0.1 (V approximately 7.
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