Background And Aim: Elderly patients are vulnerable to complications of intravenous fluid overload, however daily monitoring of fluid balance in this population has been highlighted as sub optimal by the NCEPOD. We compare current practice in fluid balance monitoring and intravenous fluid prescribing for elderly patients in a London District General Hospital to guidelines for fluid management in children issued by the National Patient Safety Agency.
Methods: This study consists of two parts: (1) a ward-based survey of fluid balance monitoring in all patients above the age of 65 receiving intravenous fluids; (2) an anonymous questionnaire completed by 20 doctors of a variety of grades and specialities on the parameters of fluid balance routinely checked by doctors prior to prescribing intravenous fluids.
Results: The results highlight that the most frequently monitored parameters of fluid balance are daily serum urea, creatinine and sodium levels (65.1% of patients receiving intravenous fluids on the wards, 85% of doctors check these levels before prescribing fluids). Initial weight is measured in one quarter of patients; daily weight is monitored in 9.4% of patients and 25% of doctors check daily weight before prescribing intravenous fluids.
Conclusion: Initial and daily weights are non-invasive parameters of fluid balance that are infrequently monitored in elderly patients receiving intravenous fluids. We propose that all elderly patients should be weighed (1) on admission to the Emergency Department, (2) prior to commencement of intravenous fluids and (3) on a regular basis, preferably daily, for the duration of intravenous fluid administration. For immobile patients, strict fluid input-output charts should be maintained as a surrogate index of changes in daily weight. We encourage consistent and accurate documentation of these non-invasive parameters on the fluid prescription charts.
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http://dx.doi.org/10.1016/j.ijsu.2007.05.012 | DOI Listing |
Health Technol Assess
January 2025
School of Medicine, Keele University, Keele, Staffordshire, UK.
Background: For people receiving haemodialysis, a balance has to be struck between removing sufficient but not too much fluid during a treatment session and maintaining any remaining kidney function they might have. In the BISTRO trial, this study sought to establish if getting the balance right might be improved by the additional use of bioimpedance, a device that measures body fluid composition to help decide how much fluid to remove during dialysis. Designing and executing this trial, which incorporated complex and repeated trial procedures that would be dependent on participant engagement, presented challenges that demanded effective public and patient involvement.
View Article and Find Full Text PDFIndian J Crit Care Med
November 2024
Department of EMS and Critical Care, Sir HN Reliance Foundation Hospital & Research Centre, Mumbai, Maharashtra, India.
Introduction: Fluid administration is a commonly practiced intervention in the intensive care unit (ICU) with normal saline being the preferred fluid. We sought to understand the current practice of fluid administration and choice of fluids in Indian ICUs and its effect on renal outcomes.
Materials And Methods: The Indian Society of Critical Care Medicine (ISCCM)-endorsed multicenter prospective observational study was conducted on practice of fluid administration in critically ill patients between May 1, 2020, and January 31, 2023.
Biochem Pharmacol
January 2025
Division of Pharmacodynamics, Faculty of Pharmacy, Keio University, Tokyo, Japan. Electronic address:
Sepsis is a life-threatening condition caused by severe infection and often complicates acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) due to the collapse of the oxidative and inflammatory balance induced by microbial pathogens, including lipopolysaccharides (LPS). In sepsis-related ARDS/ALI, NADPH oxidase (NOX) and toll-like receptors (TLR) in neutrophils and macrophages are key players in initiating oxidative and inflammatory imbalances. Although NOX and TLR activation has been linked to carbon monoxide (CO), the mechanism by which CO affects sepsis-related ARDS/ALI through NOX and TLR remains unknown.
View Article and Find Full Text PDFClin Sci (Lond)
January 2025
Center for Interdisciplinary Research in Biology, College de France, Institut National de la Santé et de la Recherche Médicale, Paris, France.
Apelin, a (neuro) vasoactive peptide, plays a prominent role in controlling water balance and cardiovascular functions. Apelin and its receptor co-localize with vasopressin in magnocellular vasopressinergic neurons. Apelin receptors (Apelin-Rs) are also expressed in the collecting ducts of the kidney, where vasopressin type 2 receptors are also present.
View Article and Find Full Text PDFPediatr Nephrol
January 2025
NIHR Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, London, UK.
Acute kidney injury (AKI) in paediatric kidney transplant recipients is common. Infection including urinary tract infection (UTI) and rejection are the most common causes in children. Surgical complications often cause AKI early post-transplant, whereas BK polyomavirus nephropathy rarely occurs in the first month post-transplant.
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