Objective: The aim of this study is to evaluate the involvement of tumor necrosis factor (TNF)-alpha in endometrial tissue remodeling during the perimenstrual period.
Study Design: Human endometrial stromal cells (ESCs) were isolated from eight premenopausal patients in the late secretory phase. The effects of TNF-alpha on the contractility of cultured ESCs were investigated by collagen gel contraction assay. The effects of TNF-alpha on the proliferation of ESCs were also assessed by a modified methylthiazoletetrazolium assay.
Results: TNF-alpha significantly upregulated the collagen gel contractility of ESCs in a dose-dependent manner. TNF-alpha did not affect ESC proliferation.
Conclusion: The results suggest that TNF-alpha may promote endometrial tissue repair by stimulating the contraction of the extracellular matrix by ESCs. By regulating ESC function during the perimenstrual period, TNF-alpha may be involved in the physiological tissue remodeling of the cyclic endometrium.
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