Burkholderia pseudomallei, a natural saprophyte widely distributed in soil, stagnant waters of endemic areas, is said to infect humans through breaks in the skin or through inhalation causing protean clinical manifestations including fatal septicaemia. A case of septicaemia in a elderly female diabetic due to B. pseudomallei following a history of fall is being reported with complete details.
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Indian J Otolaryngol Head Neck Surg
January 2025
Department of Microbiology, JIPMER, Puducherry, India.
Meliodosis is an infectious disease also called whitemore's disease that can be fatal and is caused by the bacteria . This facultative intracellular aerobic gram-negative bacterium is typically transmitted through direct contact with contaminated water or soil (Currie et al. in Seminars in Respiratory and Critical Care Medicine 36:111-125, 2015).
View Article and Find Full Text PDFAm J Trop Med Hyg
March 2025
Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Ciudad de México, México.
Melioidosis, caused by Burkholderia pseudomallei, is an emerging infectious disease in Mexico. In November to December 2023, five cases of melioidosis were reported in Baja California Sur, Mexico, after Hurricane Norma. Burkholderia pseudomallei was isolated from the five patients, four of whom died.
View Article and Find Full Text PDFCurr Res Microb Sci
February 2025
Department of Community & Family Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Melioidosis, caused by , is an emerging disease in Odisha, a state in eastern coastal India. Difficult to diagnose, the disease is likely to be severely underreported. Seroprevalence studies in the general population are deemed necessary for an estimate of melioidosis endemicity and to explore the associated risk factors.
View Article and Find Full Text PDFActa Crystallogr F Struct Biol Commun
April 2025
Department of Chemistry and Biochemistry, Northern Illinois University, 1425 Lincoln Highway, DeKalb, IL 60115, USA.
The methylerythritol phosphate (MEP) pathway is a metabolic pathway that produces the isoprenoids isopentyl pyrophosphate and dimethylallyl pyrophosphate. Notably, the MEP pathway is present in bacteria and not in mammals, which makes the enzymes of the MEP pathway attractive targets for the discovery of new anti-infective agents due to the reduced chances of off-target interactions leading to side effects. There are seven enzymes in the MEP pathway, the fifth of which is IspF.
View Article and Find Full Text PDFPeerJ
March 2025
Faculty of Medicine, Mahasarakham University, Maha Sarakham, Thailand.
Background: is a soil- and water-dwelling bacterium that causes the life-threatening infection melioidosis. Patients typically acquire this infection through environmental exposure, so reducing levels in the environment could mitigate the risk of infection. is a biological control agent that synthesizes a diverse range of antimicrobial substances targeting other microorganisms.
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