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Characterization of Clinicopathological Features and Autoantibody Profiles in Patients with Cutaneous Lupus Erythematous: A Single-Center Retrospective Study.
Am J Clin Dermatol
January 2025
Department of Dermatology, University of Michigan, Ann Arbor, MI, USA.
Background: Cutaneous lupus erythematosus (CLE) is an autoimmune condition characterized by a wide range of clinical manifestations and limited treatment options. There is little research on the impact of commonly used diagnostic tests including antinuclear antibodies (ANA) and extractable nuclear antigens (ENA) on disease course or responsiveness to treatment.
Objective: This single-center retrospective cohort study aims to address this gap by characterizing clinicopathological characteristics, patient demographics, and treatment response among patients with CLE.
[Clinical associations of anti-Jo1 antibodies in a Moroccan population].
Ann Biol Clin (Paris)
November 2024
Laboratoire d'Immunologie, Centre de Recherche Clinique, CHU Mohammed VI, Marrakech, Maroc, Laboratoire de Recherche en Biosciences, Faculté de Médecine et de Pharmacie, Université Cadi Ayyad, Marrakech, Maroc.
Anti-Jo1 antibodies are usually known markers of myositis. However, they can be associated with different pathologies. We aimed to determine the immuno-clinical characteristics of patients with positive anti-Jo1.
View Article and Find Full Text PDFDeficiency of adenosine deaminase 2 (DADA2) presented with bilateral renal subcapsular hematoma: a case report and literature review.
Ann Med Surg (Lond)
November 2024
Palestine Medical Complex, Internal Medicine, Ramallah, State of Palestine.
Article Synopsis
- Adenosine deaminase 2 (DADA2) deficiency is an autoinflammatory disease caused by mutations in the ADA2 gene, leading to various symptoms and potential complications like renal subcapsular hematoma.
- An 18-year-old female with a history of optic neuritis experienced severe flank pain and inflammatory symptoms, and imaging confirmed bilateral renal subcapsular hematomas, leading to the consideration of DADA2 based on her symptoms and family history.
- The patient was treated successfully with immunosuppressives, resulting in significant improvement and reduction of the hematomas, highlighting the importance of early diagnosis and treatment in managing DADA2 effectively.
Different patterns of longitudinal changes in antinuclear antibodies titers in children with systemic lupus erythematosus and Sjögren's syndrome.
Lupus
December 2024
Division of Rheumatology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Objective: to investigate the trend of autoantibody titers during a 2-year follow-up in pediatric systemic lupus erythematosus (pSLE) and pediatric Sjögren's syndrome (pSS).
Methods: Autoantibodies testing was performed every 3-4 months during 2 years from disease onset in a cohort of children with pSLE and pSS.
Results: We enrolled 21 children with pSLE and 22 children with pSS.
ANA-positive versus ANA-negative Antiphospholipid Antibody-positive Patients: Results from the APS ACTION Clinical Database and Repository.
Rheumatology (Oxford)
October 2024
University Center of Excellence on Nephrologic, Rheumatologic and Rare Diseases (ERK-Net, ERN-Reconnect and RITA-ERN Member) with Nephrology and Dialysis Unit and Center of Immuno-Rheumatology and Rare Diseases (CMID), Coordinating Center of the Interregional Network for Rare Diseases of Piedmont and Aosta Valley, San Giovanni Bosco Hub Hospital, Turin, Italy.
Article Synopsis
- - This study examined the occurrence and effects of antinuclear antibodies (ANA) in patients with antiphospholipid antibodies (aPL) but without other systemic autoimmune diseases, using data from the APS ACTION Registry.
- - Among the 430 analyzed patients, 56% tested positive for ANA, revealing significant links between ANA positivity and various autoimmune features like hematologic issues and joint involvement.
- - Despite the presence of these autoimmune characteristics in ANA-positive patients, the study found no connection between ANA status and complications related to thrombosis or pregnancy; interestingly, ANA-negative patients had more pregnancies and live births.
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