In order to explore the relationship between learning progress and working memory characteristics, the psychoacoustic testing of 42 persons (20-65 years old) of medical staff taught a novel science (informatics) was carried out. The subjects were divided into three age groups: 20-35, 36-50, and 51-65-year-olds. Acoustical test consisted of a set of 12 target words (professional informatics terms) presented through headphones and subsequent presentation of a random succession of 12 target and 12 masking words (all of them being professional informatics terms). Listeners had to recognize the target words. The stepwise linear regression analysis revealed a link between the progress in acquisition of the new material and characteristics of acoustical working memory, whose role in learning progress increased with age. Because the memory efficiency reduction was found in subjects older than 35 years, it was supposed that age-related changes in characteristics of the acoustical working memory were responsible for the decline in ability to learn novel material.
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As of 2023, 69% of adults and 81% of teens in the U.S. use social media.
View Article and Find Full Text PDFUnlabelled: Sensory filtering - prioritizing relevant stimuli while ignoring irrelevant ones - is crucial for animals to adapt and survive in complex environments. While this phenomenon has been primarily studied in organisms with complex nervous systems, it remains unclear whether simpler organisms also possess such capabilities. Here, we studied temporal information processing in , a freshwater planarian flatworm with a primitive nervous system.
View Article and Find Full Text PDFUnlabelled: While visual working memory (WM) is strongly associated with reductions in occipitoparietal 8-12 Hz alpha power, the role of 4-7 Hz frontal midline theta power is less clear, with both increases and decreases widely reported. Here, we test the hypothesis that this theta paradox can be explained by non-oscillatory, aperiodic neural activity dynamics. Because traditional time-frequency analyses of electroencephalopgraphy (EEG) data conflate oscillations and aperiodic activity, event-related changes in aperiodic activity can manifest as task-related changes in apparent oscillations, even when none are present.
View Article and Find Full Text PDFBr J Psychiatry
January 2025
Douglas Mental Health University Institute, Department of Psychiatry, McGill University, Montreal, Canada.
Background: Working memory deficit, a key feature of schizophrenia, is a heritable trait shared with unaffected siblings. It can be attributed to dysregulation in transitions from one brain state to another.
Aims: Using network control theory, we evaluate if defective brain state transitions underlie working memory deficits in schizophrenia.
Alzheimers Res Ther
January 2025
MMDN, Univ Montpellier, EPHE, INSERM, Montpellier, France.
Background: Fluoroethylnormemantine (FENM), a new Memantine (MEM) derivative, prevented amyloid-β[25-35] peptide (Aβ)-induced neurotoxicity in mice, a pharmacological model of Alzheimer's disease (AD) with high predictive value for drug discovery. Here, as drug infusion is likely to better reflect drug bioavailability due to the interspecies pharmacokinetics variation, we analyzed the efficacy of FENM after chronic subcutaneous (SC) infusion, in comparison with IP injections in two AD mouse models, Aβ-injected mice and the transgenic APP/PSEN1 (APP/PS1) line.
Methods: In Aβ-treated mice, FENM was infused at 0.
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