Novel genetic findings about papillary thyroid carcinoma identify BRAF gene as a subject of great interest. Involvement of BRAF gene in pathogenesis of PTC, diagnostic value and the putative prognostic significance of its T1799A mutation are summarized in this article. Furthermore, a particular attention is focused to the role of pre-operative detection of BRAF mutation in the FNAB specimens of thyroid nodules and to the use of this gene as target for an effective cancer therapy.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4618204 | PMC |
| http://dx.doi.org/10.1155/2007/489604 | DOI Listing |
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