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Innovative biomarkers TCN2 and LY6E can significantly inhibit respiratory syncytial virus infection.
J Transl Med
September 2024
Department of Laboratory Medicine, Wuxi No. 2 People's Hospital, Wuxi, Jiangsu, China.
Background: Respiratory syncytial virus (RSV) is a prominent etiological agent of lower respiratory tract infections in children, responsible for approximately 80% of cases of pediatric bronchiolitis and 50% of cases of infant pneumonia. Despite notable progress in the diagnosis and management of pediatric RSV infection, the current biomarkers for early-stage detection remain insufficient to meet clinical needs. Therefore, the development of more effective biomarkers for early-stage pediatric respiratory syncytial virus infection (EPR) is imperative.
View Article and Find Full Text PDFDysregulation of iron transport-related biomarkers in blood leukocytes is associated with poor prognosis of early trauma.
Heliyon
March 2024
Department of Emergency, Xijing Hospital, The Air Force Medical University, Xi'an, China.
Objective: The early targeted and effective diagnosis and treatment of severe trauma are crucial for patients' outcomes. Blood leukocytes act as significant effectors during the initial inflammation and activation of innate immunity in trauma. This study aims to identify hub genes related to patients' prognosis in blood leukocytes at the early stages of trauma.
View Article and Find Full Text PDFFTY720 requires vitamin B-TCN2-CD320 signaling in astrocytes to reduce disease in an animal model of multiple sclerosis.
Cell Rep
December 2023
Sanford Burnham Prebys Medical Discovery Institute, 10901 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address:
Vitamin B (B) deficiency causes neurological manifestations resembling multiple sclerosis (MS); however, a molecular explanation for the similarity is unknown. FTY720 (fingolimod) is a sphingosine 1-phosphate (S1P) receptor modulator and sphingosine analog approved for MS therapy that can functionally antagonize S1P. Here, we report that FTY720 suppresses neuroinflammation by functionally and physically regulating the B pathways.
View Article and Find Full Text PDFExperimental Analysis of Tear Fluid and Its Processing for the Diagnosis of Multiple Sclerosis.
Sensors (Basel)
June 2023
Department of Magnetism, Institute of Experimental Physics, Slovak Academy of Sciences, Watsonova 47, 040 01 Košice, Slovakia.
A pilot analysis of the tear fluid of patients with multiple sclerosis (MS) collected by glass microcapillary was performed using various experimental methods: liquid chromatography-mass spectrometry, Raman spectroscopy, infrared spectroscopy, and atomic-force microscopy. Infrared spectroscopy found no significant difference between the tear fluid of MS patients and the control spectra; all three significant peaks were located at around the same positions. Raman analysis showed differences between the spectra of the tear fluid of MS patients and the spectra of healthy subjects, which indicated a decrease in tryptophan and phenylalanine content and changes in the relative contributions of the secondary structures of the polypeptide chains of tear proteins.
View Article and Find Full Text PDFCyanocobalamin promotes muscle development through the TGF-β signaling pathway.
Food Funct
December 2022
Laboratory of Cell and Developmental Biology, Northeast Agricultural University, Harbin 150030, China.
Article Synopsis
- Cyanocobalamin (Vitamin B12) is crucial for growth and can't be produced by animals; its role in muscle development is explored in this study.
- CNCbl promotes the differentiation of C2C12 cells and activates key proteins in the TGF-β signaling pathway, but inhibiting its receptor CD320 reduces its effects on muscle markers.
- The study also shows that injecting CNCbl speeds up muscle repair in mice and enhances muscle fiber growth through upregulation of specific proteins related to muscle development.
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