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Response of 21 Hyaluronic Acid Fillers to Recombinant Human Hyaluronidase.
Plast Reconstr Surg Glob Open
December 2023
Division of Oculofacial Plastic Surgery, Department of Ophthalmology, USC Roski Eye Institute, Keck School of Medicine of USC, Los Angeles, Calif.
Background: One benefit of hyaluronic acid fillers is the ability to dissolve them using hyaluronidase. With the increasing number of fillers entering the market, it is crucial to understand each of these fillers' responsiveness to hyaluronidase.
Methods: Twenty-one hyaluronic acid fillers of 0.
Time- and Dose-Dependent Effects of Hyaluronidase on the Degradation of Different Hyaluronan-Based Fillers In Vitro.
Plast Reconstr Surg
March 2023
From the Department of Dermatology, Medical Faculty, University Hospital Duesseldorf.
Background: Hyaluronidase (HYAL) is regarded as the standard for the management of complications associated with hyaluronan (HA)-based fillers. Therefore, the understanding of interactions of HA fillers and HYAL is essential.
Methods: Nine different commercially available HA fillers (Belotero, Juvéderm, and Restylane) with varying degrees of cross-linking were used for the analysis.
Quantifying the Digestion of Cross-Linked Hyaluronic Acid Fillers With Hyaluronidase.
Dermatol Surg
September 2021
Oculoplastic Surgery, The Jules Stein Eye Institute, University of California, Los Angeles.
Background: Adverse events due to hyaluronic acid fillers (HAFs) may be treated with hyaluronidase, an enzyme that cleaves bonds within hyaluronic acid. This study reviews the efficacy of currently available hyaluronidase preparations in breaking down commercial, cross-linked HAFs.
Methods: Three HAFs were used in this study (Restylane, Juvederm Voluma, and Belotero [BEL] Balance).
Response of twelve different hyaluronic acid gels to varying doses of recombinant human hyaluronidase.
J Plast Reconstr Aesthet Surg
April 2021
USC Roski Eye Institute, Keck School of Medicine, 1450 San Pablo St., 4th Floor, Los Angeles, CA 90033, United States. Electronic address:
Purpose: Hyaluronic acid (HA) fillers can be reversed with hyaluronidase, but their dose responses are not well-characterized. We evaluated 12 fillers' in vitro responses to varying doses of recombinant human hyaluronidase (RHH).
Methods: For the 12 HA gels, 0.
Prospective in vivo evaluation of three different hyaluronic acid gels to varying doses of hyaluronidase with long-term follow-up.
J Plast Reconstr Aesthet Surg
April 2021
Ophthalmic Surgeons and Consultants of Ohio, Eye Center of Columbus, The Ohio State University, Columbus 43221, OH, United States.
Article Synopsis
- The study investigates the effects of different doses of hyaluronidase on various injectable hyaluronic acid dermal fillers, specifically Restylane-L, Juvéderm Ultra, and Juvéderm Voluma.
- It involved random intradermal injections in 9 subjects, measuring changes in diameter, elevation, and firmness, with effects observed as early as 30 minutes and up to 4 years post-injection.
- Results showed that while all fillers responded to hyaluronidase, Voluma required higher doses for effective dissolution, while Restylane was most responsive at lower doses but also dissolved faster on its own.
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