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Adult Outcomes of Childhood Wheezing Phenotypes Are Associated with Early-Life Factors.
J Pers Med
December 2024
Respiratory Biomedical Research Centre, University Hospital Southampton, Southampton SO16 6YD, UK.
While the phenotypic diversity of childhood wheezing is well described, the subsequent life course of such phenotypes and their adult outcomes remain poorly understood. We hypothesized that different childhood wheezing phenotypes have varying longitudinal outcomes at age 26. We sought to identify factors associated with wheezing persistence, clinical remission, and new onset in adulthood.
View Article and Find Full Text PDFMaternal Allergic Disease Phenotype and Infant Birth Season Influence the Human Milk Microbiome.
Allergy
December 2024
School of Molecular Sciences, The University of Western Australia, Crawley, WA, Australia.
Early infancy is a critical period for immune development. In addition to being the primary food source during early infancy, human milk also provides multiple bioactive components that shape the infant gut microbiome and immune system and provides a constant source of exposure to maternal microbiota. Given the potential interplay between allergic diseases and the human microbiome, this study aimed to characterise the milk microbiome of allergic mothers.
View Article and Find Full Text PDFThe Role of Neutrophils in Allergic Disease.
Clin Exp Immunol
December 2024
Discipline of Paediatrics, School of Medicine, Trinity College Dublin, Ireland.
Neutrophils are short-lived cells of the innate immune system and represent 50-70% of the circulating leucocytes. Their primary role is antimicrobial defence which they accomplish through rapid migration to sites of inflammation followed by phagocytosis, degranulation and the release of neutrophil extracellular traps (NETosis). While previously considered terminally-differentiated cells, they have been shown to have great adaptability and to play a role in conditions ranging from cancer to autoimmunity.
View Article and Find Full Text PDFKeeping up with Recent Developments in Immunodeficiency.
Ann Allergy Asthma Immunol
December 2024
Division of Pediatric Pulmonology, Allergy and Immunology, Department of Pediatrics, Medical University of South Carolina, South Carolina, USA. Electronic address:
Inborn Errors of Immunity are a rapidly expanding group of monogenetic disorders affecting the immune system. Advancements in genetic testing and functional validation studies have accelerated the pace of IEI gene discovery and mechanism of disease, particularly in the past five years. To keep up with this rapid expansion, the International Union of Immunological Societies (IUIS) Expert Committee has periodically, since 1999, released updated IEI classifications with corresponding genotypic and phenotypic catalogues with its most recent update in 2022.
View Article and Find Full Text PDFDistinct IgE sensitization profiles in chronic urticaria: a comparative study with classic allergic diseases.
Front Immunol
December 2024
Department of Dermatology, Southwest Hospital, Army Medical University, Chongqing, China.
Article Synopsis
- - Chronic urticaria (CU) is linked to atopy, indicated by IgE sensitization, but specific information on its characteristics in CU is limited.
- - An analysis of 1149 patients revealed 33.1% of CU patients had positive specific IgE and 49.0% had elevated total IgE, showing higher rates than healthy controls but lower than classic allergic diseases.
- - The findings suggest CU patients have a distinct IgE sensitization profile that differs from traditional allergic diseases, highlighting the need for further research into its underlying causes and clinical implications.
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