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Metallo-azapeptides: Controlled Metal Chelation to Peptide Backbone Nitrogen.
J Am Chem Soc
January 2025
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, United States.
We present the first approach to controlled metal chelation of peptide backbones, where the anchoring site is an aza-amino acid nitrogen and the directionality of chelation events is dictated by the acidity of neighboring NHs. Selective backbone chelation precludes the need for metal-binding side chains and/or free - or -termini in peptides. We show that the presence and location of an aza-amino acid impact complex formation and report the first X-ray crystal structures of azapeptides bound to palladium and nickel.
View Article and Find Full Text PDFTetrafluoro(aryl)sulfanylated Bicyclopentane Crystals That Self-Destruct upon Cooling.
J Am Chem Soc
January 2025
Department of Chemistry, University of California, Davis, 1 Shields Avenue, Davis, California 95616, United States.
Whereas single crystals of organic compounds that respond to heat or light have been reported and studied in detail, studies on crystalline organic compounds that elicit an extreme mechanical response are relatively rare in the chemical literature. A tetrafluoro(aryl)sulfanylated bicyclopentane synthesized in our laboratory was discovered to exhibit such behavior; i.e.
View Article and Find Full Text PDFHigh-pressure, high-temperature synthesis at 12 GPa between 750 and 1000°C for 30 to 300 min yields the last missing rare-earth metal monogermanide, YbGe. Powder and single-crystal X-ray diffraction measurements reveal that the compound crystallizes in a FeB-type structure (space group Pnma, a = 7.901(2) Å, b = 3.
View Article and Find Full Text PDFPhase Characterization and Bioactivity Evaluation of Nucleic Acid-Encapsulated Biomimetically Mineralized ZIF-8.
ACS Appl Mater Interfaces
January 2025
Ian Potter NanoBiosensing Facility, NanoBiotechnology Research Laboratory, School of Science, RMIT University, Melbourne, Victoria 3000, Australia.
Metal-organic frameworks (MOFs) provide diverse applications across a wide range of scientific disciplines, including drug/nucleic acid (NA) delivery. In the subclass of MOFs, zeolitic imidazolate framework-8 (ZIF-8) is well regarded due to its exceptional physicochemical properties. Biomolecules can be encapsulated and released under precise conditions within ZIF, making it an important material for materials science and biomedical applications.
View Article and Find Full Text PDFComputational Characterization of the Interaction of CARD Domains in the Apoptosome.
Biochemistry
January 2025
Department of Chemistry and Molecular Biology, University of Gothenburg, Göteborg 405 30, Sweden.
The apoptosome, a critical protein complex in apoptosis regulation, relies on intricate interactions between its components, particularly the proteins containing the Caspase Activation and Recruitment Domain (CARD). This work presents a thorough computational analysis of the stability and specificity of CARD-CARD interactions within the apoptosome. Departing from available crystal structures, we identify important residues for the interaction between the CARD domains of Apaf-1 and Caspase-9.
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