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Purpose: To describe novel findings seen on optical coherence tomography angiography (OCTA) and indocyanine green angiography (ICGA) in a young male patient presenting with bilateral topiramate-induced choroidal effusion.

Methods: Retrospective case report. A comprehensive ophthalmic examination was conducted and multimodal imaging techniques, including B-scan ultrasound, OCT, OCTA, and ICGA were analyzed.

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Background: Various publications have noted increases in dopamine, specifically in the mesolimbic region of the brain, to have a direct correlation to psychotic-like symptoms. Venlafaxine, a first-line medication for depression, inhibits the reuptake of both serotonin and norepinephrine. Additionally, venlafaxine weakly inhibits the reuptake of dopamine.

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Objective: Intellectual disability (ID) is associated with weight gain caused by antiepileptic drugs such as valproic acid. The present study analyzed the relationship between ID and weight loss caused by topiramate (TPM).

Methods: Seventy-eight patients with epilepsy (35 women, aged 18 to 70years) were enrolled in this prospective study.

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Hallucinations Associated with Topiramate Therapy: A Case Report and Review of the Literature.

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Department of Psychiatry and Behavioral Neurosciences, Women's Center Psychiatrist; Ambulatory Care Service, James A. Haley Veterans Hospital, University of South Florida, Morsani College of Medicine, Tampa, FL. United States.

Background: Topiramate is a medication that is approved as both monotherapy and adjunctive treatment of seizure disorder in adults and adolescents. It is also approved for migraine prophylaxis. It has been associated with many side effects, including weight loss and the development of renal stones.

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A candidate-gene association study of topiramate-induced weight loss in obese patients with and without type 2 diabetes mellitus.

Pharmacogenet Genomics

February 2016

aNeuroscience Therapeutic Area, Janssen Research & Development, LLC, Titusville, New Jersey bCVM Therapeutic Area, Janssen Research & Development, LLC, Spring House, Pennsylvania cPerlegen Sciences, Mountain View, California dAthanasiou Consulting, LLC, Fond du Lac, Wisconsin, USA.

Objective: Clinical response to topiramate can vary greatly in obese patients. Identifying genetic variants associated with treatment response could help gain insight into the mechanism of action of topiramate. Little is known about the relationship between genetic variability and topiramate treatment response.

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