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Pallidal Spike-Train Variability and Randomness Are the Most Important Signatures to Classify Parkinson's Disease and Cervical Dystonia.
Eur J Neurosci
January 2025
Case Western Reserve University, Cleveland, Ohio, USA.
Movement disorders such as Parkinson's disease (PD) and cervical dystonia (CD) are associated with abnormal neuronal activity in the globus pallidus internus (GPi). Reduced firing rate and presence of spiking bursts are typical for CD, whereas PD is characterized by high frequency tonic activity. This research aims to identify the most important pallidal spiking parameters to classify these conditions.
View Article and Find Full Text PDFDiagnosing Cerebrotendinous Xanthomatosis in a Middle-Aged Woman with Cervical Dystonia.
J Mov Disord
January 2025
Department of Neurology, Changhua Christian Hospital, Changhua, Taiwan.
Torticollis in a child with Grisel syndrome: A case report and review of the literature.
Int J Surg Case Rep
January 2025
Department of Orthopedics and Trauma Surgery, Tribhuwan University, Institute of Medicine, Kathmandu, Nepal.
Introduction And Importance: Grisel syndrome (GS) is a rare but potentially lethal condition characterized by non-traumatic atlantoaxial subluxation primarily affecting pediatric population following inflammatory condition of head and neck. Early diagnosis and prompt treatment is crucial for better management of symptoms and better outcomes.
Case Presentation: 7-years-old child present with torticollis, sudden onset progressive neck pain, restricted range of motion and bilateral lymphadenopathy after upper respiratory tract infection (URTI).
DaxibotulinumtoxinA Treatment for Laryngeal Respiratory Dystonia.
J Voice
January 2025
Department of Otolaryngology-Head and Neck Surgery, UCSF Voice and Swallowing Center, UCSF School of Medicine, San Francisco, CA. Electronic address:
Background: Laryngeal respiratory dystonia (LRD) is diagnosed based on clinical presentation, patient history, and physical examination. Key indicators include dyspnea, desynchronized breathing patterns, and laryngoscopic findings that reveal vocal fold adduction during inspiration. Treatment for LRD remains controversial and often yields limited effectiveness.
View Article and Find Full Text PDFEngaging dystonia networks with subthalamic stimulation.
Proc Natl Acad Sci U S A
January 2025
Center for Brain Circuit Therapeutics, Department of Neurology, Brigham & Women's Hospital, Harvard Medical School, Boston, MA 02115.
Deep brain stimulation is an efficacious treatment for dystonia. While the internal pallidum serves as the primary target, recently, stimulation of the subthalamic nucleus (STN) has been investigated. However, optimal targeting within this structure and its surroundings have not been studied in depth.
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