AI Article Synopsis
- - The study explored how mild hypothermia influences infarct volume, angiogenesis, and brain-derived neurotrophic factor (BDNF) levels after a stroke, using techniques like TTC staining and ELISA to analyze effects.
- - Results showed that mild hypothermia led to a decrease in total infarct volume and an increase in BDNF levels compared to the normothermic group.
- - Additionally, mild hypothermia significantly improved aspects of angiogenesis, like increased microvessel diameter and branching, suggesting that BDNF may partially contribute to these effects in ischemic brain tissue.
Article Abstract
In the present study, we investigated the effect of mild hypothermia on infarct volume, angiogenesis and brain-derived neurotrophic factor (BDNF) level after stroke. After permanent middle cerebral artery occlusion, mild hypothermia was induced immediately and maintained for 24h. 2,3,5-Triphenyltetrazolium chloride (TTC) staining, laser scanning confocal microscopy (LSCM) and ELISA were performed to assay infarct volume, angiogenesis and BDNF level in the ischemic boundary zone (IBZ), respectively. Compared with normothermic group, mild hypothermia reduced total infarct volume and increased endogenous BDNF level. And the microvessel diameter, the number of vascular branch points and the vessel surface area were significantly increased in the mild hypothermia group. These findings suggest that mild hypothermia enhances angiogenesis in ischemic brain, which might be enhanced in part via BDNF.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neulet.2007.03.072 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!