AI Article Synopsis
- The cumulative risk of developing primary peritoneal carcinoma (PPC) after prophylactic bilateral oophorectomy is reported to be between 3.5% and 4.3%, primarily presenting at advanced stages (III or IV).
- A 56-year-old woman with a BRCA1 mutation discovered a liver mass during breast MRI screening after previously having surgery with no malignancy.
- Following chemotherapy and surgery for a grade 3 serous papillary adenocarcinoma, she has been disease-free for three years, marking a unique case of localized BRCA-related PPC outside the pelvic area.
Article Abstract
Background: The reported cumulative risk of developing primary peritoneal carcinoma (PPC) one to 20 years after prophylactic bilateral oophorectomy is 3.5% to 4.3%. Virtually all reported cases have been stage III or IV.
Case: During MRI screening of the breasts, an incidental mass on the surface of the liver was identified in a 56-year-old BRCA1 mutation carrier who had undergone prophylactic bilateral salpingo-oophorectomy several years previously with no evidence of malignancy. After four cycles of chemotherapy a localized, grade 3 serous papillary adenocarcinoma was resected followed by further chemotherapy and radiation. She remains disease-free 3 years post-treatment.
Conclusion: The literature on PPC after prophylactic oophorectomy is reviewed. To the best of our knowledge, this is the first description of an apparently localized case of BRCA related PPC outside the pelvis.
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| http://dx.doi.org/10.1016/j.ygyno.2007.05.037 | DOI Listing |
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