AI Article Synopsis
- Lobular neoplasia (LN) is linked to an increased risk of bilateral breast cancer, but there's no clear management guideline for it.
- A study of 52 patients indicated that core needle biopsy often underrepresents the severity of LN, as 19% of cases had more serious conditions like invasive carcinoma or ductal carcinoma in situ found during surgical excision.
- Follow-up surgical excision is recommended for cases with masses or pleomorphic LN, while patients without such indicators should have annual mammograms to monitor their ongoing risk.
Article Abstract
Lobular neoplasia (LN) is a risk factor for bilateral breast cancer without consensus as to its appropriate management. The authors report on a retrospective multi-institutional study concerning 52 patients in whom a diagnosis of LN was made after core needle biopsy (CNB) and who subsequently underwent surgical excision. The excision specimens revealed seven cases of invasive carcinoma and three cases of ductal carcinoma in situ, indicating an underestimation of lesions at CNB in 19% of cases, and in particular in those patients with pleomorphic LN, and when clinical, radiological masses were detected. This lesion is increasingly being diagnosed by CNB due to widespread screening. Follow-up surgical excision should be performed in order to examine the whole lesion in the case of masses or when the histologic specimen reveals a pleomorphic subtype. In other cases, annual mammographic surveillance should be undertaken due to the persistent long-term risk of developing bilateral breast cancer.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.breast.2007.04.005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!