Nociceptin/orphanin FQ (N/OFQ) and its receptor (NOP) are involved in various biological functions including pain. High density of NOP receptor has been found in the ventrolateral periaqueductal gray (vlPAG), the main output pathway involved in descending pain-control system. The aim of our work was to evaluate the involvement of the N/OFQ/NOP system in the modulation of MOP analgesia in the rat vlPAG using UFP-101, a selective NOP antagonist. N/OFQ significantly blocked DAMGO (a selective MOP agonist) analgesia, while UFP-101 enhanced the effect of the opioid given at a subanalgesic dose. These results confirm our hypothesis of an antiopioid role for N/OFQ in the vlPAG.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.peptides.2007.05.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hyperoside ameliorates neuropathic pain by modulating the astroglial reactivity in the vlPAG.
Neuropharmacology
December 2024
Department of Integrative Medicine and Neurobiology, School of Basic Medical Science, Institutes of Integrative Medicine, Shanghai Key Laboratory of Acupuncture Mechanism and Acupoint Function, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institutes of Brain Science, Shanghai Medical College, Fudan University, Shanghai, 200032, China. Electronic address:
Hyperoside, a natural flavonoid, exhibits a wide range of biological activities, including analgesic effects on acute and chronic inflammatory pain. This study illustrates that repeated intraperitoneal administration or microinjection of hyperoside into the ventrolateral periaqueductal grey (vlPAG) alleviated mechanical allodynia, cold allodynia, and abnormal gait induced by spared nerve injury (SNI) in male mice. Furthermore, repeated hyperoside administration suppressed SNI-induced astrocyte reactivity in the vlPAG.
View Article and Find Full Text PDFAcute Single-Unit Multi-Electrode Recordings from the Brainstem of Head-Fixed Mice.
J Vis Exp
October 2024
Department of Anesthesiology, University of Virginia;
Article Synopsis
- - Silicon multielectrode recordings help researchers study neuronal activity at high temporal resolution, but accessing deep brain structures like the brainstem poses challenges due to the risk of injuring major blood vessels.
- - To avoid these dangers, researchers developed an angled probe insertion technique that targets the brainstem while bypassing large veins, allowing for better access to various brain regions.
- - Using this method, scientists successfully recorded neuronal activity in the ventrolateral periaqueductal gray (vlPAG) related to REM sleep, enhancing the understanding of its connection to anesthesia in mice.
[Research progress of acupuncture in improving pain emotion by regulating functions of anterior cingulate cortex].
Zhen Ci Yan Jiu
October 2024
College of Acupuncture-Moxibustion and Tuina, Gansu University of Chinese Medicine, Lanzhou 730000, China.
Pain emotion is a negative emotion caused by pain, which seriously affects the patients' physical and psychological health. The anterior cingulate cortex (ACC) is a key brain region in the occurrence and regulation of pain and painful emotion. In this paper, we summed up the relevant progress of researches on acupuncture improvement of pain emotion from neurotransmitters and receptors, cellular signaling pathways and neural circuits of ACC, in order to provide a basis for further research.
View Article and Find Full Text PDFHemoglobin α-derived peptides VD-hemopressin (α) and RVD-hemopressin (α) are involved in electroacupuncture inhibition of chronic pain.
Front Pharmacol
October 2024
Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Institute of Neuroscience, Translational Medicine Institute, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Introduction: Knee osteoarthritis (KOA) is a chronic degenerative bone metabolic disease that primarily affects older adults, leading to chronic pain and disability that affect patients' daily activities. Electroacupuncture (EA) is a commonly used method for the treatment of chronic pain in clinical practice. Previous studies indicate that the endocannabinoid system is involved in EA analgesia, but whether endocannabinopeptide VD-hemopressin (α) and RVD-hemopressin (α) derived from hemoglobin chains are involved in EA analgesia is unclear.
View Article and Find Full Text PDFThe Orexin OX Receptor-Dependent Pathway Is Implicated in the Development of Overactive Bladder and Depression in Rats Exposed to Corticosterone.
Neurourol Urodyn
January 2025
Second Department of Gynecology, Medical University of Lublin, Lublin, Poland.
Article Synopsis
- * Various tests including the forced swim test, cystometry, and biochemical analyses were conducted to evaluate the impact of a 7-day TCS administration on bladder function and depressive behaviors.
- * Results indicate that TCS improved bladder overactivity and reversed depressive signs, suggesting a potential link between the orexin system and both urinary bladder function and depression.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!