Development of a mimotope-based vaccine against CD20 antigen.

Protein Pept Lett

Center of Biotechnology, the Fourth Military Medical University, 17 Changle West Road, Xi'an, China.

Published: October 2007

CD20, a B-cell-specific protein, is a primary target for immunotherapy of B-cell lymphomas. We used a mimotopes of CD20 to construct vaccines for B-cell-related disorders. The immunogenicity of the vaccines was tested in BALB/c mice. Results of this study suggest that the mimotope may be a useful tool for the construction of a functional vaccine to treat B cell-related disorders.

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http://dx.doi.org/10.2174/092986607780989958DOI Listing

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