By means of angiography, made in 20 patients with rigidity of the first toes due to osteoarthrosis, there have been revealed chronic deficiency of blood circulation in the foot tissues, especially in its antero-internal section. Blood circulation deficiency is due either to the congenital anomaly of the foot vessels or to the consequences of their traumatic injuries. Blood supply deficiency results in degenerative-dystrophic changes of the first metatarsophalangeal articulations with development of their rigidity, aggravated by post-ischemic contracture of the foot muscles.
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Cells
December 2024
Beijing Institute of Brain Disorders, Capital Medical University, Beijing 100054, China.
Neurovascular coupling (NVC) refers to the process of local changes in cerebral blood flow (CBF) after neuronal activity, which ensures the timely and adequate supply of oxygen, glucose, and substrates to the active regions of the brain. Recent clinical imaging and experimental technology advancements have deepened our understanding of the cellular mechanisms underlying NVC. Pathological conditions such as stroke, subarachnoid hemorrhage, cerebral small vascular disease, and vascular cognitive impairment can disrupt NVC even before clinical symptoms appear.
View Article and Find Full Text PDFNano Lett
January 2025
Department of Radiology, Interventional Radiology Innovation at Stanford (IRIS), Stanford University School of Medicine, Palo Alto, California 94304, United States.
In this study, we designed a nanoscale platform for sustained amino acid delivery to support transplanted pancreatic islets. The platform features mesoporous silica nanoparticles (MSNPs) loaded with glutamine (G), an essential amino acid required for islet survival and function, and coated with polydopamine (PD). We investigated various PD concentrations (0.
View Article and Find Full Text PDFA A Pract
January 2025
From the Department of Anesthesia, Perioperative and Pain Medicine, Lahey Hospital and Medical Center, Burlington, Massachusetts.
After vascular puncture and catheterization, arteries can have many complications that impede blood flow such as vasospasm, thrombosis, and emboli generation, among other complications. Treatment depends on severity of ischemic symptoms and can range from as mild as applying local heat packs to surgical thrombectomy. We present a case of digital ischemia secondary to vascular puncture that was successfully treated with a supraclavicular nerve block, resulting in the vascular surgery team canceling an emergent surgery.
View Article and Find Full Text PDFInvestig Clin Urol
January 2025
National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine, Incheon, Korea.
Purpose: To investigate the therapeutic potential of eliminating insulin-like growth factor-binding protein 5 (IGFBP5) expression in improving erectile function in mice with cavernous nerve injury (CNI)-induced erectile dysfunction (ED).
Materials And Methods: Eight-week-old male C57BL/6 mice were divided into four groups: a sham-operated group and three CNI-induced ED groups. The CNI-induced ED groups were treated with intracavernous injections 3 days before the CNI procedure.
J Biomech Eng
January 2025
State Key Laboratory of Clean Energy Utilization, Zhejiang University, Yuquan Campus, 38 Zheda Road, Hangzhou 310027, Zhejiang, China; Shanghai Institute for Advanced Study of Zhejiang University, Zhangjiang Guochuang Center phase, No.799, Dangui Road, Shanghai 200120, China.
The carotid and vertebral arteries are principal conduits for cerebral blood supply and are common sites for atherosclerotic plaque formation. To date, there has been extensive clinical and hemodynamic reporting on carotid arteries; however, studies focusing on the hemodynamic characteristics of the vertebral artery (VA) are notably scarce. This article presents a systematic analysis of the impact of VA diameter and the angle of divergence from the subclavian artery (SA) on hemodynamic properties, facilitated by the construction of an idealized VA geometric model.
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