Objective: Despite the ever ongoing development in the examination procedures, it is still impossible to exactly diagnose a large percentage of patients with vertebral and back (low-back and neck) pains. This is due to an insufficiently clear connection between symptoms, pathological changes and results from the imaging techniques. Besides a morphological and neurological examination, a grave diagnostic attention should be given to a possible muscular dysfunction. A simple electromechanical device called muscle dynamometer (MD01) has been constructed for the purpose of enabling to effortlessly, objectively and precisely examine the muscle power-output in the lumbar spine area and reveal a possible, often found and therapeutically treated, dysfunction of the deep stabilizing spine system (DSSS).
Methods: The six-week-rehabilitation-course, aimed at correcting the body posture and strengthening the DSSS muscles, during which two groups of healthy adolescents (girls and boys, aged 12-16) have been obtained.
Results: The statistically significant change (p<0.001) between the values of input and output measurements of the condition of DSSS.
Conclusions: The effectiveness of therapeutical training is confirmed and the objectification of the condition of the DSSS muscles by means of the muscle dynamometer (MD01) is verified.
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Purpose Of The Study: Intraarticular fractures of the distal femur rank among the most severe musculoskeletal injuries. Various treatment options, such as plate osteosynthesis or retrograde nailing, can be employed. This study aims to evaluate the clinical outcomes and complications of intraarticular distal femoral fractures treated with retrograde femoral nail, with particular emphasis on C3 fractures.
View Article and Find Full Text PDFIn Silico Pharmacol
January 2025
Phyto-medicine and Computational Biology Laboratory, Department of Biochemistry, Adekunle Ajasin University, Akungba-Akoko, Ondo State Nigeria.
Unlabelled: Lead optimization is vital for turning hit compounds into therapeutic drugs. This study builds upon a prior in silico research, where the hit compounds had better binding affinity and stability compared to a reference drug. Using a genetic algorithm, 12,500 analogs of the top compounds from the prior study were generated.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
College of Food Science and Engineering, Jilin Agricultural University, Changchun, China; Jilin Province Innovation Center for Food Biological Manufacture, Jilin Agricultural University, Changchun, China; National Processing Laboratory for Soybean Industry and Technology, Changchun, China; National Engineering Laboratory for Wheat and Corn Deep Processing, Changchun, China. Electronic address:
In this study, the potential of using an emulsion gel based on whey protein concentrate (WPC) and pullulan (PUL) to encapsulate and deliver astaxanthin (AST) was investigated. PUL concentration was observed to affect the microstructure of WPC/PUL/AST emulsion gels, and the performance of emulsion gels was evaluated by encapsulation efficiency, simulated gastrointestinal digestion, storage stability, hardness, and water holding capacity tests. The WPC/PUL/AST emulsion gels had the highest encapsulation efficiency, gastrointestinal digestion retention, and bioaccessibility of (91.
View Article and Find Full Text PDFWaste Manag
January 2025
College of Civil Engineering, Nanjing Forestry University, Nanjing, 210037, China.
The utilization of natural waste gravel soil as base course material contributes to environmental protection and carbon emission reduction. The purpose of this research is to establish a new model for automated gradation design of the composite soil stabilizer-stabilized waste gravel soil (CSSWGS). A gradation range of CSSWGS has been proposed.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
State Key Laboratory of Common Mechanism Research for Major Diseases, Department of Biochemistry & Molecular Biology, Medical Primate Research Center, Neuroscience Center, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, 100005, China.
The development of the mammalian neocortex is precisely regulated by temporal gene expression, yet the temporal regulatory mechanisms of cortical neurogenesis, particularly how radial glial cells (RGCs) sequentially generate deep to superficial neurons, remain unclear. Here, the hnRNP family member Syncrip (hnRNP Q) is identified as a key modulator of superficial neuronal differentiation in neocortical neurogenesis. Syncrip knockout in RGCs disrupts differentiation and abnormal neuronal localization, ultimately resulting in superficial cortical layer defects as well as learning and memory impairments in mice.
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