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Effects of long-acting versus short-acting granulocyte colony stimulating factor after radiotherapy in gynecologic malignancies: a prospective observational cohort study.
BMC Cancer
December 2024
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Shuaifuyuan No. 1, Beijing, Dongcheng District, 100730, China.
Little is known about the role of the protective effects of granulocyte colony-stimulating factor (G-CSF) in patients after radiotherapy. The aim of the present study was to explore the prophylactic effects of long-acting granulocyte colony-stimulating factor (G-CSF) on febrile neutropenia (FN) and myelosuppression in chemotherapy patients with gynecologic malignancies after pelvic radiotherapy. Patients voluntarily participated in a study group (long-acting G-CSF for all chemotherapy cycles) and a control group (short-acting G-CSF) after they were educated about G-CSF utilization.
View Article and Find Full Text PDFLack of Prophylactic Cranial Irradiation for Extensive Small-Cell Lung Cancer in Real Life, with the Emergence of Immunotherapy.
Cancers (Basel)
December 2024
Oncology Radiotherapy Department, Assistance Publique des Hôpitaux de Marseille, Aix-Marseille Université, 13005 Marseille, France.
Background: Prophylactic cranial irradiation (PCI) is recommended to decrease the incidence of brain metastases (BM) in extensive-stage small-cell lung cancer (ESSCLC) without BM after response to chemotherapy. However, PCI is associated with significant neurocognitive effects, and new studies are debating its benefits. Moreover, the introduction of immunotherapy in the management of the disease has raised new questions, and there is a lack of data on PCI and immunotherapy.
View Article and Find Full Text PDFRisk Factor Analysis and Prediction of Para-Aortic Lymph Node Metastases in Locally Advanced Cervical Cancer.
Cancer Med
December 2024
Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China.
Background And Purpose: The indications of prophylactic extended-field radiotherapy (EFRT) remain uncertain. This study aims to identify the risk factors for para-aortic lymph node (PALN) metastases in locally advanced cervical cancer (LACC) and determine which part of patients may benefit from prophylactic EFRT.
Materials And Methods: Between January 2015 and July 2023, a single-center retrospective analysis was performed on patients with stages IB3 and IIA2-IVA cervical cancer.
Long-term outcome in cervical lymph node-positive nasopharyngeal carcinoma following IMRT with one-step cervical nodal CTV delineation by geometric-anatomic expansion from nodal GTV: A double-center experience.
Int J Radiat Oncol Biol Phys
December 2024
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian, China; Fujian Key Laboratory of Translational Cancer Medicine, Fuzhou, Fujian, China. Electronic address:
Background: To report long-term results of cervical node-positive (CLN+) nasopharyngeal carcinoma (NPC) patients treated with IMRT with one-step nodal clinical target volume (CTVn) delineation by geometric-anatomic expansion from the nodal gross target volume (GTVn).
Materials: CLN+ NPC treated with the same one-step-CTVn delineation in two Chinese academic centers were pooled for this study. GTVn was prescribed to 70 Gy equivalent, CTVn1 was omitted, CTVn2 was prescribed to 45-55 Gy equivalent and defined as GTVn + 3 mm geometric expansion (5 mm if radiological extranodal extension-positive, rENE+) + elective nodal regions defined by anatomic boundary of cervical nodal levels.
The Role of Radiotherapy in Hematologic Malignancies in Children, Adolescents, and Young Adults.
Semin Radiat Oncol
January 2025
Department of Radiation Oncology, BC Cancer, Vancouver Center, Vancouver, Canada.
Hematologic cancers in pediatric, adolescent, and young adult populations include a diverse spectrum of malignancies. The cornerstone of treatment is multiagent chemotherapy. While radiation therapy (RT) is highly effective and played a pivotal role historically, its use has evolved.
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