Laboratório de Antibióticos, Departamento de Microbiologia e Parasitologia, Universidade Federal de Santa Catarina, Florianópolis, SC, 88040-970, Brazil.
Published: June 2007
AI Article Synopsis
Article Abstract
A mixture of the two new flavonols 8-hydroxy-3, 4', 5, 6, 7-pentamethoxyflavone (1) and 8-hydroxy-3, 3', 4', 5, 6, 7-hexamethoxyflavone (2) was isolated from a commercial sample of Citrus aurantifolia. An array of one- (1HNMR, {1H}-13C NMR, and APT-13C NMR) and two-dimensional NMR techniques (COSY, NOESY, HMQC and HMBC) was used to achieve the structural elucidation and the complete 1H and 13C chemical shift assignments of these natural compounds. In addition, the antifungal activity of these compounds against phytopathogenic and human pathogenic fungi was investigated.
A heptasaccharide was isolated from an active fraction of Trillium tschonoskii using HILIC and high-temperature PGC chromatography methods. UHPLC-Q/TOF-MS analysis gave this oligosaccharide a degree of polymerization (DP) of 7 and MS/MS showed that it has a six-carbon aldehyde glucan structure with the possible chain 1 → 4 connected. The structure was determined by series 1D and 2D NMR in two solvents DO and DMSO‑d.
Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance (BMRZ), Johann Wolfgang Goethe University, Max-von-Laue-Str. 7, 60438, Frankfurt/Main, Germany.
Ephrin receptors regulate intercellular communication and are thus involved in tumor development. Ephrin receptor A2 (EphA2), in particular, is overexpressed in a variety of cancers and is a proven target for anti-cancer drugs. The N-terminal ligand-binding domain of ephrin receptors is responsible for the recognition of their ligands, ephrins, and is directly involved in receptor activation.
Unlabelled: Exercise in warm environments increases thermal/cardiovascular strain and decreases gastrointestinal (GI) integrity and endurance performance. However, laboratory-based studies have provided little to/no facing airflow, potentially exacerbating these effects, particularly for cycling, where convective cooling may be a major contributor to thermal balance.
Purpose: This study investigated the effect of cycling in a warm vs temperate environment with sufficient facing airflow on exogenous glucose use, performance, and GI responses.
Purpose: We investigated if a bout of HIIE is more efficacious at reducing postprandial hyperglycemia than an isocaloric bout of MICE.
Methods: Nineteen healthy physically active individuals (21% women) completed three trials in a randomized order: i) HIIE cycling consisting of 5 bouts of 4 min at 83 ± 9% of subjects' maximal oxygen consumption (V˙O2 MAX) with active recoveries at 53 ± 8% for a total of 50 min; ii) MICE cycling at 65 ± 8% of V˙O2 MAX for 50 min, and iii) CONTROL no exercise. All trials were followed by a standard oral glucose tolerance test (OGTT) ingesting 74 grams of glucose traced with 1 gram of uniformly labeled [13C]-glucose.
The study focuses on the synthesis and anti-inflammatory effects of thirteen new substituted-isoxazole derivatives (5a-5m), which are important compounds in medicinal chemistry.
The main goals were to create these new compounds, evaluate how they interact with COX-1/2 enzymes using computational methods, and test their anti-inflammatory effects in lab animals.
Results show that three of the compounds exhibited significant anti-inflammatory properties and low toxicity, suggesting potential for further medicinal use.
