Objective: To evaluate effectiveness of 5 mW laser irradiation in the treatment of chronic tinnitus.
Study Design: Prospective, randomised, double-blind study.
Methods: This investigation included 66 ears in 45 patients with chronic unilateral or bilateral tinnitus. A 5 mW laser with a wavelength of 650 nm, or placebo laser, was applied transmeatally for 15 minutes, once daily for a week. A questionnaire was administered which asked patients to score their symptoms on a five-point scale, before and two weeks after laser irradiation. A decrease of one scale point, regarding the loudness, duration and degree of annoyance of tinnitus, was accepted to represent an improvement.
Results: The loudness, duration and degree of annoyance of tinnitus were improved, respectively, in up to 48.8, 57.7 and 55.5 per cent of the patients in the active laser group. No significant improvement was observed in the placebo laser group.
Conclusion: Transmeatal, low power (5 mW) laser irradiation was found to be useful for the treatment of chronic tinnitus.
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http://dx.doi.org/10.1017/S0022215107009619 | DOI Listing |
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Department of Bioscience, Federal University of São Paulo, R. Silva Jardim, 136, Vila Mathias, Santos, Sao Paulo, 11015-020, Brazil.
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View Article and Find Full Text PDFJ Colloid Interface Sci
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Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 106335 Taiwan. Electronic address:
Photothermal therapy (PTT) using thermal and tumor microenvironment-responsive reagents is promising for cancer treatment. This study demonstrates an effective PTT nanodrug consisting of hollow-structured, thermally sensitive polydopamine nanobowls (HPDA NB), molybdenum sulfide (MoS) nanozyme, and tirapazamine (TPZ; a hypoxia-responsive drug), with a structure of HPDA@TPZ/MoS NBs which is hereafter denoted as HPTZMoS NBs. With the Fenton-like activity, the HPTZMoS NBs in the presence of HO catalyze the formation of hydroxyl radicals, providing chemodynamic therapy (CDT) effect and deactivating glutathione.
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