AI Article Synopsis
- The study focuses on creating and testing new compounds called methylamino piperidinyl substituted oxazolidinones for their antibacterial properties.* -
- These compounds were tested against a variety of Gram-positive bacteria to see their effectiveness, particularly against strains that are resistant to treatment.* -
- One specific compound, 4i, demonstrated strong antibacterial activity, performing similarly to established antibiotics like linezolid, especially against linezolid-resistant Staphylococcus aureus.*
Article Abstract
Design and synthesis of a few novel methylamino piperidinyl substituted oxazolidinones are reported. Their antibacterial activities have been evaluated in a MIC assay against broader panel of both susceptible and resistant Gram-positive strains. (S)-N-{3-[3-Fluoro-4-(methyl-{1-[3-(5-nitrofuran-2-yl)-acryloyl]-piperidin-4-yl}-amino)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide 4i has shown comparable antibacterial activity to linezolid and eperezolid in the MIC assay, additionally compound 4i showed good antibacterial activity with an in vitro MIC value of 2-4 microg/mL against linezolid resistant Staphylococcus aureus (linezolid 16 microg/mL).
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| http://dx.doi.org/10.1016/j.bmcl.2007.06.075 | DOI Listing |
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