We describe three instructive cases of neurologic melioidosis that demonstrate the variable nature of clinical manifestations and disease pathology. The appropriate duration and choice of parenteral and oral antimicrobial therapy for neurologic melioidosis are also discussed.
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Indian J Microbiol
December 2024
Spine Surgery, Apollo Multispecialty Hospital, Kolkata, India.
Melioidosis rarely presents with spinal involvement, which may lead to neurological complications. It's endemic to Thailand and Australia, but rare in India. Patients with diabetes, immunocompromised states, and chronic renal failure are at high risk of developing melioidosis, which can present with localized or disseminated abscess collection.
View Article and Find Full Text PDFTrans R Soc Trop Med Hyg
November 2024
Department of Microbiology, Kasturba Medical College, Manipal Academy of Higher Education, Manipal 576104, India.
Introduction: The tunnel sign (linear contrast enhancement along the corticospinal tract) can aid in the early diagnosis of neuromelioidosis, a potentially fatal condition requiring urgent diagnosis.
Methodology: We retrospectively analyzed the hospital data of all patients with culture-confirmed melioidosis between 2018 and 2023 in a tertiary care hospital in South India. MRI scans of patients with neuromelioidosis were reviewed for the presence of the tunnel sign.
Indian J Med Microbiol
December 2024
Department of Microbiology, Velammal Medical College Hospital and Research Institute, Madurai, India. Electronic address:
Neurologic melioidosis warrants attention in view of its rarity and lethal consequences. We performed a retrospective review of culture confirmed neurologic melioidosis reported between 2017 and 2023. Thirteen patients were identified with median age 43 years and all but three were males.
View Article and Find Full Text PDFIn the United States in 2021, an outbreak of 4 cases of Burkholderia pseudomallei, the etiologic agent of melioidosis and a Tier One Select Agent (potential for deliberate misuse and subsequent harm), resulted in 2 deaths. The causative strain, B. pseudomallei ATS2021, was unintentionally imported into the United States in an aromatherapy spray manufactured in India.
View Article and Find Full Text PDFEur J Case Rep Intern Med
April 2024
Department of Infectious Disease, Rashid Hospital, Dubai Health, Dubai, United Arab Emirates.
Background: Melioidosis is an infection caused by , a Gram-negative bacterium. It is a disease endemic to Southeast Asia and northern Australia although its global incidence has been rising. It most commonly infects people with certain identified risk factors such as diabetes, alcoholism, thalassemia, and underlying chronic disease involving lungs, kidney and liver.
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