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Multiphoton and Harmonic Imaging of Microarchitected Materials.
ACS Appl Mater Interfaces
January 2025
Laser Thermal Laboratory, Department of Mechanical Engineering, University of California, Berkeley, California 94720, United States.
Article Synopsis
- Microadditive manufacturing enables the creation of intricate nano- and microscale components, leading to advancements in various industries.
- This research explores two-photon and three-photon fluorescence imaging, along with third-harmonic generation microscopy, to analyze complex lattice structures produced by multiphoton lithography.
- The study reveals that multiphoton fluorescence imaging provides better depth penetration and nondestructive identification of internal modifications and defects, improving quality control in microadditively manufactured products.
Deep learning-based aberration compensation improves contrast and resolution in fluorescence microscopy.
Nat Commun
January 2025
Laboratory of High Resolution Optical Imaging, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, USA.
Optical aberrations hinder fluorescence microscopy of thick samples, reducing image signal, contrast, and resolution. Here we introduce a deep learning-based strategy for aberration compensation, improving image quality without slowing image acquisition, applying additional dose, or introducing more optics. Our method (i) introduces synthetic aberrations to images acquired on the shallow side of image stacks, making them resemble those acquired deeper into the volume and (ii) trains neural networks to reverse the effect of these aberrations.
View Article and Find Full Text PDFQuantitative Histopathology Analysis Based on Label-free Multiphoton Imaging for Breast Cancer Diagnosis and Neoadjuvant Immunotherapy Response Assessment.
Int J Biol Sci
January 2025
Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Accurate diagnosis and assessment of breast cancer treatment responses are critical challenges in clinical practice, influencing patient treatment strategies and ultimately long-term prognosis. Currently, diagnosing breast cancer and evaluating the efficacy of neoadjuvant immunotherapy (NAIT) primarily rely on pathological identification of tumor cell morphology, count, and arrangement. However, when tumors are small, the tumors and tumor beds are difficult to detect; relying solely on tumor cell identification may lead to false negatives.
View Article and Find Full Text PDFA domed window chamber for multi-modality optical imaging.
Biotechniques
January 2025
Biomedical Engineering, The University of Arizona, Tucson, AZ, USA.
Current dorsal skin flap window chambers with flat glass windows are compatible with optical coherence tomography (OCT) and multiphoton microscopy (MPM) imaging. However, light sheet fluorescence microscopy (LSFM) performs best with a cylindrical or spherical sample located between its two 90° objectives and when all sample materials have the same index of refraction (). A modified window chamber with a domed viewing window made from fluorinated ethylene propylene (FEP), with n similar to water and tissue, was designed.
View Article and Find Full Text PDFAdvances in Imaging of Traumatic Nerve Injuries.
J Am Acad Orthop Surg
December 2024
From the Department of Orthopaedic Surgery, University of Utah, Salt Lake City, UT (Graesser), the Washington University School of Medicine in St. Louis, Mallinckrodt Institute of Radiology, St. Louis, MO (Parsons), and the Department of Orthopaedic Surgery, Washington University School of Medicine in St. Louis, St. Louis, MO (Olafsen, Dy, and Brogan).
Traumatic peripheral nerve injuries represent a spectrum of conditions and remain challenging to diagnose and prognosticate. High-resolution ultrasonography and magnetic resonance neurography have emerged as useful diagnostic modalities in the evaluation of traumatic peripheral nerve and brachial plexus injuries. Ultrasonography is noninvasive, is able to rapidly interrogate large areas and multiple nerves, allows for a dynamic assessment of nerves and their surrounding anatomy, and is cost-effective.
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