AI Article Synopsis
- The study focuses on a patient who developed resistance to daptomycin while dealing with a persistent infection from vancomycin-intermediate Staphylococcus aureus (VISA).
- The researchers found that the VISA cells had a reduced level of muramic acid O-acetylation, which is a new characteristic not previously associated with VISA strains.
- A few of the bacterial isolates also had a specific mutation in the mprF gene, which may be linked to this resistance.
Article Abstract
We analyzed the emergence of daptomycin nonsusceptibility in a patient with persistent vancomycin-intermediate Staphylococcus aureus (VISA) bacteremia. The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2043240 | PMC |
| http://dx.doi.org/10.1128/AAC.00559-07 | DOI Listing |
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