'I feel like a traffic light stuck on red. My friends ask me if I'm having hot flushes but this isn't flushes, it's permanent and I'm still having periods.' Carol is describing her facial appearance. She is 42 years of age, has had trouble controlling her weight all her life and has gained 10 kg over the past 2-3 years.
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The New Sydenham Society's Atlas of Portraits of Diseases of the Skin - an Educational Tool.
Clin Dermatol
December 2024
Department of Dermatology, Yale School of Medicine, New Haven, CT.
In 1859, the New Sydenham Society undertook the publication of an Atlas of Portraits of Diseases of the Skin, having been inspired by Ferdinand Ritter von Hebra's Atlas der Hautkrankheiten. Utilizing information contained in Sir Jonathan Hutchinson's Descriptive Catalogue of the New Sydenham's Society Atlas of Portraits of Diseases of the Skin (published in 1869 and 1875), an exhibit of twenty-five illustrations of cutaneous disorders, along with teaching points, was held at the Harvey Cushing/John Jay Whitney Medical Library at Yale University. It served as an educational tool for dermatologists, dermatology residents, medical students, and even physicians from other specialties.
View Article and Find Full Text PDFComplicated iatrogenic Cushing's syndrome induced by topical clobetasol propionate in a child with psoriasis: a case report and review of the literature.
J Med Case Rep
December 2024
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Long-term use of oral or parenteral corticosteroids is the most common cause of hypothalamic-pituitary-adrenal axis suppression and iatrogenic Cushing's syndrome. Still, iatrogenic Cushing's syndrome occurs rarely following the administration of topical corticosteroids.
Case Presentation: This case study discusses the misuse of a high-potency corticosteroid cream by an Iranian 5-year-old male with plaque-form psoriasis, resulting in Cushingoid symptoms including moon face, buffalo hump, red striae, and weight gain.
Addisonian Pigmentation - The Great Mimicker - A Review.
Indian J Dermatol
October 2024
Department of Radiology, Institute of Liver and Biliary Sciences, New Delhi, India.
Skin colour usually depends upon melanin, haemoglobin, and carotenoids. Pigmentary disorders indicate an increased amount of melanin, leading to a darker colour of the skin, called hypermelanosis. Addison's disease is a rare endocrinal disorder with severe oral and systemic manifestations.
View Article and Find Full Text PDFGlucocorticoids and mineralocorticoids in hair: facilitating accurate diagnosis of adrenal-related endocrine disorders.
Front Endocrinol (Lausanne)
November 2024
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.
Article Synopsis
- A study was conducted to investigate the presence of mineralocorticoids and glucocorticoids, particularly focusing on aldosterone and 18-hydroxycorticosterone, in hair follicles, which has not been reported before.
- Hair samples from 15 healthy volunteers were analyzed using advanced extraction and mass spectrometry techniques, allowing for the detection of various steroids without significant differences between genders.
- Notable findings included the detection of deoxycortisol, deoxycorticosterone, and 18-hydroxycorticosterone for the first time in hair, showing variability in levels for some steroids but stability in others across individuals.
Pathogenic role of acyl coenzyme A binding protein (ACBP) in Cushing's syndrome.
Nat Metab
December 2024
Metabolomics and Cell Biology Platforms, UMS AMMICa, Gustave Roussy Institut, Villejuif, France.
Cushing's syndrome is caused by an elevation of endogenous or pharmacologically administered glucocorticoids. Acyl coenzyme A binding protein (ACBP, encoded by the gene diazepam binding inhibitor, Dbi) stimulates food intake and lipo-anabolic reactions. Here we found that plasma ACBP/DBI concentrations were elevated in patients and mice with Cushing's syndrome.
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