Zetaclausenamide, which was isolated as a hepatoprotective agent from the leaves of medicinal plant Clausena lansium, was synthesized for the first time in six steps including Darzen's condensation, photoisomerization, and the final cyclization reactions.
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Genes (Basel)
December 2024
College of Landscape Architecture, Nanjing Forestry University, Nanjing 210037, China.
Background: MicroRNA159 (miR159) is a conserved miRNA found in various plant species. By regulating GAMYB-like transcription factors, miR159 is involved in diverse biological processes. , a significant traditional Chinese orchid, has unique flower shape and elegant fragrance.
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December 2024
SupraSelen Laboratory, Department of Chemistry, Universidade Federal Fluminense, Institute of Chemistry, Campus do Valonguinho, 24020-141 Niterói-RJ, Brazil.
Our research presents selective direct selenylation at the C-4 pyrazole ring using KSO as an oxidant under simple and mild conditions. This elegant synthesis involves the one-pot method under acidic conditions, thus minimizing reaction steps and waste generation. This innovative method allowed us to create a library of 4-selanylpyrazoles in good to excellent yields.
View Article and Find Full Text PDFACS Nano
January 2025
College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215006, China.
Low-temperature direct ammonia fuel cell (DAFC) stands out as a more secure technology than the hydrogen fuel cell system, while there is still a lack of elegant bottom-up synthesis procedures for efficient ammonia oxidation reaction (AOR) electrocatalysts. The widely accepted d-band center, even with consideration of the d-band width, usually fails to describe variations in AOR reactivity in many practical conditions, and a more accurate activity descriptor is necessary for a less empirical synthesis path. Herein, the upper d-band edge, ε, derived from the d-band model, is identified as an effective descriptor for accurately establishing the descriptor-activity relationship.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Biochemistry, University of Illinois, Urbana, IL 61801.
Infections caused by gram-negative pathogens continue to be a major risk to human health because of the innate antibiotic resistance endowed by their unique cell membrane architecture. Nature has developed an elegant solution to target gram-negative strains, namely by conjugating toxic antibiotic warheads to a suitable carrier to facilitate the active import of the drug to a specific target organism. Microcin C7 (McC) is a Trojan horse peptide-conjugated antibiotic that specifically targets enterobacteria by exploiting active import through oligopeptide transport systems.
View Article and Find Full Text PDFSubcell Biochem
December 2024
Centro de Biología Molecular "Severo Ochoa" (CSIC-UAM) and Department of Molecular Biology, Universidad Autónoma de Madrid, Madrid, Spain.
Icosahedral viruses exhibit elegant pathways of capsid assembly and maturation regulated by symmetry principles. Assembly is a dynamic process driven by consecutive and genetically programmed morphogenetic interactions between protein subunits. The non-symmetric capsid subunits are gathered by non-covalent contacts and interactions in assembly intermediates, which serve as blocks to build a symmetric capsid.
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