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[Septic musculoskeletal complications under immunomodulating treatment].

Z Rheumatol

January 2025

Rheumatologische Facharztpraxis Schwerin, Schwerin, Deutschland.

Infections are an important cause of morbidity and mortality in patients with inflammatory rheumatic diseases. Among these, musculoskeletal infections represent a relevant proportion as patients with rheumatoid arthritis face an increased risk of developing septic arthritis and prosthesis infections. The causes are multifactorial.

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Focal Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss.

J Inflamm Res

December 2024

Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Introduction: Septic arthritis, primarily caused by (), is a severe joint infection that leads to joint and bone damage. lipoproteins (LPPs) bind to Toll-like Receptor 2 (TLR2), inducing arthritis and localized bone loss. Aging affects TLR2 immune response to pathogens.

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Osteomyelitis and Septic Arthritis in the Darwin Prospective Melioidosis Study.

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January 2025

Department of Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia.

Background: Melioidosis is a multisystem infectious disease caused by the environmental bacterium . Osteomyelitis (OM) and septic arthritis (SA) are uncommon primary presentations for melioidosis but important secondary foci, often requiring prolonged therapy and multiple surgeries. We characterized the epidemiology, presentation, treatment, and outcomes of patients from 24 years of the Darwin Prospective Melioidosis Study (DPMS).

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Correct diagnosis and treatment of septic arthritis (SA) are essential to achieve satisfactory results and avoid lifelong consequences. Diagnosing septic arthritis is not always easy, which is why new biomarkers have been sought. Another difficulty in diagnosis is the increase in septic arthritis due to Kingella Kingae, which does not show the same signs and symptoms as classic infections.

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Objectives: Septic arthritis after anterior cruciate ligament (ACL) reconstruction is a rare but potentially devastating complication. The imaging findings associated with such infections are not well-described or quantified. The purpose of this study was to describe and quantify the frequency of the characteristic MRI findings of infection following ACL reconstruction.

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