Cell-adhesion inhibitors produced by a sea hare-derived Periconia sp.

Peribysin J and macrosphelide M have been isolated from a strain of Periconia byssoides originally isolated from the sea hare Aplysia kurodai. Their absolute stereostructures have been elucidated on the basis of spectroscopic analyses using 1D and 2D NMR techniques and some chemical transformations including the modified Mosher's method. These fungal metabolites inhibited the adhesion of human-leukemia HL-60 cells to human-umbilical-vein endothelial cells (HUVEC).