AI Article Synopsis
- A child with Mycobacterium avium infection showed worsening disease despite nearly 5 years of treatment with various antibiotics chosen based on lab tests.
- A test revealed the child had a problem with her monocytes (a type of white blood cell) that made them less effective at killing bacteria, which could be fixed in a lab setting.
- Treatment with indomethacin, a type of anti-inflammatory drug, improved the child's immune response and led to significant, though short-lived, clinical improvement.
Article Abstract
A child with disseminated disease due to Mycobacterium avium had progressive disease in spite of 4.5 years of therapy with multiple antimicrobial agents selected on the basis of in vitro sensitivity testing of her organism. A defect in monocyte bactericidal activity was detected which was corrected in vitro by exposure of the patient's monocytes to indomethacin and normal serum. Indomethacin therapy resulted in normalization of monocyte bactericidal activity and striking, albeit temporary, clinical improvement.
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| http://dx.doi.org/10.1007/BF00918801 | DOI Listing |
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