Low-dose aspirin use does not improve in vitro fertilization outcomes in poor responders.

Objective: To assess if aspirin improves pregnancy outcome in patients undergoing in vitro fertilization (IVF) with a diagnosis of poor response.

Design: Retrospective cohort analysis.

Setting: Academic private practice.

Patient(s): 1250 poor-responder patients undergoing IVF.

Intervention(s): Low-dose (81 mg) aspirin before and during an IVF cycle.

Main Outcome Measure(s): Live-birth rate.

Result(s): Patients taking 81 mg of aspirin had statistically significantly higher basal antral follicle counts, more days of stimulation, more ampules of gonadotropins used, higher peak estradiol levels, and more follicles that were > or = 14 mm in diameter on the day of human chorionic gonadotropin administration. There was a decrease in the overall fertilization rate for the patients taking aspirin. There was no difference in IVF outcome rates (implantation, pregnancy, loss, or live birth).

Conclusion(s): Patients with a diagnosis of poor response who were taking a regimen of 81 of mg aspirin showed an increase in many IVF stimulation parameters and a decrease in fertilization rates. No improvement secondary to 81-mg aspirin intake was found in IVF outcome rates.