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The 3' UTR Polymorphism rs1054564 Is Associated with Diabetes and Subclinical Atherosclerosis.
Int J Mol Sci
November 2024
Research Unit on Lipids and Atherosclerosis, Universitat Rovira i Virgili, 43201 Reus, Spain.
Growth differentiation factor 15 (GDF15) is a stress-response cytokine related to a wide variety of metabolic diseases. However, the impact of GDF15-specific genetic variants on the abovementioned conditions is poorly known. The aim of this study was to assess the impact of selected GDF15 single-nucleotide polymorphisms (SNPs) on metabolic disturbances and subclinical atherosclerosis.
View Article and Find Full Text PDFFerroptosis-related gene signature predicts prognosis and immune microenvironment in prostate cancer.
Transl Androl Urol
September 2024
Department of Urology, Lianshui People's Hospital of Kangda College Affiliated to Nanjing Medical University, Huai'an, China.
Background: Ferroptosis, an iron-dependent form of programmed cell death, significantly impacts cancer, yet its link to prostate cancer (PCa) prognosis remains underexplored. This study aims to develop and validate a ferroptosis-related gene signature to predict PCa prognosis and immune microenvironment differences, potentially identifying therapeutic targets.
Methods: RNA-sequencing data of 478 PCa patients and corresponding clinical data were downloaded from The Cancer Genome Atlas (TCGA) database.
Identification of cytokine signatures in HIV‑infected individuals with and without co‑infection.
Biomed Rep
September 2024
Division of Tropical and Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin Central Hospital, Bandung, West Java 40161, Indonesia.
Individuals with human immunodeficiency virus (HIV) infection are susceptible to immune system dysregulation, particularly during co-infection with (MTB). Although there is an association between cytokine profiles and HIV-MTB co-infection, little is known about the cytokine-related host immune response mechanism to HIV-MTB co-infection. Therefore, the present study aimed to analyze expression of cytokines IL-17A, IFN-γ, TNF, IL-2, IL-10, IL-6 and IL-4 in individuals with HIV-MTB co-infection.
View Article and Find Full Text PDFSerum growth differentiation factor 15 is a novel biomarker with high predictive capability for liver cancer occurrence in patients with MASLD regardless of liver fibrosis.
Aliment Pharmacol Ther
August 2024
Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Osaka, Japan.
Article Synopsis
- A recent study explored the use of serum growth differentiation factor-15 (GDF15) as a biomarker to identify high-risk patients with metabolic dysfunction-associated steatotic liver disease (MASLD) who need closer follow-up for liver cancer.
- Researchers analyzed GDF15 levels in over 500 MASLD patients and found that high levels were linked to increased liver cancer risk, regardless of fibrosis stage or standard risk indicators like the Fib-4 index.
- The findings suggest that GDF15 could be a convenient and effective indicator for determining which MASLD patients should undergo regular monitoring for liver cancer, thus potentially improving patient outcomes.
Characterization of immune microenvironment in patients with HPV-positive and negative head and neck cancer.
Sci Data
October 2023
Department of Radiation Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, West Huanhu Road, West River District, Tianjin, 300060, China.
Human papillomavirus (HPV) status strongly predicts positive clinical outcomes in patients with head and neck squamous cell cancer (HNSCC); however, the potential reasons have not been fully elucidated. Here, we characterized the immune context in HPV+ and HPV- HNSCC by integrating scRNA-seq and bulk RNA-seq data. In scRNA-seq data, HPV + HNSCC displayed increased B cells, plasma cells, CD4 effector T cells, and decreased macrophages and mast cells.
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