Background. One of the key elements in the examination and evaluation of body posture is defining the shape and size of anterior-posterior curvature of the spine and the location of symmetrical bone points in the trunk area. The aim of our study was to determine which somatic features and parameters of spinal curvature in the sagittal plane show statistically significant differences among children with given types of body posture. Material and methods. We examined 298 children (146 boys and 152 girls) attending four primary schools in Wroclaw, Poland. The examinations were carried out in specially prepared darkened rooms, using computer equipment to evaluate body posture. Results. The most significant similarities regardless of gender were observed in the inclination of the lumbosacral spine (a) and the angle of thoracic kyphosis, as well as in the size and index of thoracic kyphosis. The highest values in these parameters were found in children with lordotic posture, in whom the lowest values were found in the inclination of the upper thoracic segment (g) and the angle and size of lumbar lordosis. However, in children with kyphotic posture the most significant differences were observed in the length of thoracic kyphosis, and the least significant in the actual length of lumbar lordosis. Conclusions. The size parameters and indexes of anterior-posterior spinal curvature appeared to be the least differentiating factors among posture types. The strongest similarity of posture types was found in somatic features and weight-height ratios.
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Discov Oncol
January 2025
Second Department of Oncology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
Introduction: We conducted a panoramic analysis of GBN5 expression and prognosis in 33 cancers, aiming to deepen the systematic understanding of GBN5 in cancer.
Materials And Methods: We employed a multi-omics approach, including transcriptomic, genomic, proteomic, single-cell cytomic, spatial transcriptomic, and genomic data, to explore the prognostic value and potential oncogenic mechanisms of GBN5 across pan-cancers from multiple perspectives.
Results: We found that GBN5 was differentially expressed in multiple tumors and showed early diagnostic value.
Biology (Basel)
January 2025
Division of Thoracic Surgery, Cantonal Hospital Lucerne, 6000 Lucerne, Switzerland.
In 2001, two enzyme-encoding genes were recognized in the fruit fly . The genetic material, labeled and , encodes ribonuclease-type enzymes with slightly diverse target substrates. The human orthologue is .
View Article and Find Full Text PDFMedicine (Baltimore)
January 2025
Department of Otolaryngology, Hangzhou Red Cross Hospital (Zhejiang Hospital of Integrated Traditional Chinese and Western Medicine), Hangzhou, Zhejiang, China.
T-helper 17 (Th17) cells significantly influence the onset and advancement of malignancies. This study endeavor focused on delineating molecular classifications and developing a prognostic signature grounded in Th17 cell differentiation-related genes (TCDRGs) using machine learning algorithms in head and neck squamous cell carcinoma (HNSCC). A consensus clustering approach was applied to The Cancer Genome Atlas-HNSCC cohort based on TCDRGs, followed by an examination of differential gene expression using the limma package.
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January 2025
Department of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin, 150081, China.
Early diagnosis and disease management based on risk stratification have a very positive impact on colon adenocarcinoma (COAD) prognosis. It is of positive significance to further explore risk stratification of COAD patients and identify predictive molecular biomarkers. PANoptosis is defined as a form of inflammatory cell death regulated by PANoptosome, with common features of pyroptosis, apoptosis and necroptosis.
View Article and Find Full Text PDFJ Pers Med
December 2024
Divisione di Cardiologia, Policlinico Casilino, Via Casilina, 00169 Roma, Italy.
: Takotsubo syndrome (TTS) shares many clinical features with acute myocardial infarction (AMI); however, its underlying pathophysiology remains elusive due to specific characteristics (i.e., reversibility, presence of stressors, and low mortality rate).
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