Objective: The aim of this study was to confirm an association between low social rank (SR) and anorexia nervosa (AN), and to test the hypotheses that low SR is (a) present after recovery from the illness, (b) mediates an association between increased childhood interpersonal adversity (CIA) and AN.
Method: Participants were 18 women with active AN, 13 recovered women, and 16 healthy controls. General and specific psychopathology, childhood adversity, and indices of SR were assessed using self-report measures.
Results: Low SR was observed in both the active and the recovered AN groups and was a significant mediator in the relationship between CIA and AN status.
Conclusion: CIA may contribute to the risk of developing AN via its impact on the development of low SR. The latter may be a shared risk factor for AN and affective disorder, and could be a useful therapeutic target.
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http://dx.doi.org/10.1002/eat.20427 | DOI Listing |
J Neural Transm (Vienna)
January 2025
Human Anatomy, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, Pisa, 56100, PI, Italy.
Anorexia nervosa (AN) represents an eating disorder, which features the highest rate of mortality among all psychiatric disorders. The disease prevalence is increasing steadily, and an effective cure is missing. The neurobiology of the disease is largely unknown, and only a few studies were designed to disclose specific brain areas, where altered neural transmission may occur.
View Article and Find Full Text PDFBackground: Anorexia nervosa has the highest mortality rate of any psychiatric disorder, and purging behaviors can cause a fatal electrolyte and acid-base imbalance. Routine laboratory testing during inpatient care is essential because these patients often provide inaccurate information about their diet and purging behaviors. However, blood gas analysis for an acid-base evaluation is rarely performed in the psychiatric setting because psychiatrists are not accustomed to evaluating the results.
View Article and Find Full Text PDFEat Weight Disord
January 2025
Eating Disorders Unit, Department of Neuroscience, University of Turin, Via Cherasco 15, 10126, Turin, Turin, Italy.
Eating disorders (EDs) pose significant challenges to mental and physical health, particularly among adolescents and young adults, with the COVID-19 pandemic exacerbating risk factors. Despite advancements in psychosocial and pharmacological treatments, improvements remain limited. Early intervention in EDs, inspired by the model developed for psychosis, emphasizes the importance of timely identification and treatment initiation to improve prognosis.
View Article and Find Full Text PDFAntibodies (Basel)
December 2024
IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
: Anorexia nervosa (AN) is a complex psychiatric disorder characterized by an extreme fear of gaining weight, leading to severe calorie restriction and weight loss. Beyond its psychiatric challenges, AN has significant physical consequences affecting multiple organ systems. Recent research has increasingly focused on the interplay between autoantibodies, oxidative stress, and nutritional state in this condition.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!