Nontypeable Haemophilus influenzae (NTHi) is an important cause of illness among children. To further understand the role of laterally transferred genes in NTHi colonization and otitis media, the prevalence of hicAB, lav, tnaA, and hifBC was determined among 44 middle ear and 35 throat NTHi isolates by dot-blot hybridization.
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http://dx.doi.org/10.1111/j.1574-6968.2007.00822.x | DOI Listing |
Toxins (Basel)
October 2020
Institute of Biosciences, Life Sciences Center, Vilnius University, LT-1025 Vilnius, Lithuania.
is a ubiquitous environmental bacterium that has recently emerged as a multidrug-resistant opportunistic pathogen causing bloodstream, respiratory, and urinary tract infections. The connection between the commensal environmental and the opportunistic pathogen strains is still under investigation. Bacterial toxin-antitoxin (TA) systems have been previously associated with pathogenic traits, such as biofilm formation and resistance to antibiotics, which are important in clinical settings.
View Article and Find Full Text PDFJ Ind Microbiol Biotechnol
June 2019
Department of Biochemical Engineering, Zhejiang Gongshang University, Hangzhou, 310018, China.
Bacterial toxin-antitoxin (TA) systems play important roles in diverse cellular regulatory processes. Here, we characterize three putative type II TA candidates from Acetobacter pasteurianus and investigate the profile of type II TA systems in the genus Acetobacter. Based on the gene structure and activity detection, two-pairs loci were identified as the canonical hicAB and higAB TA systems, respectively, and DB34_01190-DB34_01195 as a putative new one without a canonical TA architecture.
View Article and Find Full Text PDFToxins (Basel)
April 2016
Department of Microbiology, Third Military Medical University, Chongqing 400038, China.
Toxin-antitoxin (TA) systems are small genetic modules that are widely distributed in the genomes of bacteria and archaea and have been proposed to fulfill numerous functions. Here, we describe the identification and characterization of a type II TA system, comprising the hicAB locus in the human opportunistic pathogen Pseudomonas aeruginosa. The hicAB locus consists of genes hicA and hicB encoding a toxin and its cognate antitoxin, respectively.
View Article and Find Full Text PDFFEMS Microbiol Lett
September 2007
Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, USA.
Nontypeable Haemophilus influenzae (NTHi) is an important cause of illness among children. To further understand the role of laterally transferred genes in NTHi colonization and otitis media, the prevalence of hicAB, lav, tnaA, and hifBC was determined among 44 middle ear and 35 throat NTHi isolates by dot-blot hybridization.
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